P-32: Histological Study of Cauda Epididymis in Adult Rats Treated with Methylphenidate

Background: Methylphenidate commonly known as Ritalin is one of the most common medications. The administration of Ritalin leads to increase of the activity of central nervous system. Because of this property, Ritalin may be used for maintaining alertness and improving of attention which may lead to increase of the risk of substance abuse in some cases. There is a little data about the effects of long term treatment with Ritalin on body organs involved in fertility ability. This study was designed to investigate the time dependent effects of MPH on the activity of male reproductive system. Materials and Methods: Methylphenidate was administrated to adult rats (10 mg/kg/day) in two experimental groups for period of two and eight weeks. Histological study was performed on the cauda epididymis for evaluation of microscopic changes. Results: The administration of methylphenidate for eight weeks caused some alteration in epididymis tissue such as transformation of nucleus, reduction of cilia and decrement of height of epithelial cells of ducts. Severe reduction of epididymal sperm population and increment of connective tissue volume also was seen. The above mentioned changes were seen in other treatment group but in lower intensity. Conclusion: The findings of this study indicate that, long term administration of methylphenidate can adversely damage the male fertility due to impairment of structure and function of male reproductive system.