P-25: Role of Oocyte Morphology on ARTOutcome

Background: The cause of fertilization failure in IVF is most often due to the absence of sperm penetration but the reason why fertilization does not occur when intracytoplasmic sperm injection (ICSI) is applied is not clear. However some intrinsic oocyte problems may also be responsible for fertilization failure. It has been reported that 13% of unfertilized oocytes after IVF show morphological abnormalities.When cumulus cells were denuded for ICSI, 60-70% of all oocytes retrieved showed abnormal morphological characteristics. Materials and Methods: Data collection was done using the internet to search Medline for obtaining evidence- based medicine reviews. Cross-references were obtained from key articles. Websites of government bodies and medical associations were searched for guidelines relating to Role of oocyte morphology on ART outcome. Results: In women undergoing ICSI for fertilization assessment of OCCC morphology is pointless, since there is no correlation between OCCC morphology and fertilization and cleavage. first polar body morphology assessment may not serve as a reliable marker of oocyte quality and competence. embryo developmental rate and implantation potential is not affected by the Extracytoplasmic abnormalities of the oocyte. only severe cytoplasmic defects such as organelle clustering/centrally located granulation, appearance of SER clusters, and certain types of fluid-filled vacuoles should be considered as abnormalities.Conclusion: It seems morphological assessment of oocyte is necessary as a predictor for ART outcome. But effects of some abnormalities on fertilization and embryo development are controversial.