P-227: The Survey on Endometrial Thickness and Echo Pattern Changes in Consecutive Cycles of Clomiphene Citrate Therapy in Infertile Women

Background: One of the most common causes of infertility in women is ovulatory dysfunction (PCOS) and the choice of treatment is clomiphene citrate. One of the mechanism of dichotomy between the rate of ovulation and pregnancy is anti estrogenic effects of clomiphene citrate on endometrium. According to its long half life, the anti estrogenic effects probably exacerbate in consecutive cycles. We studied the effect of consecutive cycles of clomiphene citrate on endometrial thickness and echo pattern. Materials and Methods: Only patients with PCOS were included in this study. Patients received clomiphene citrate with dose of 100 mg from day 3 to day 7. Each woman was evaluated using Trans vaginal ultrasound on 13th to 16th. For patients who had at least one mature follicle, endometrial thickness and echo pattern were evaluated. During treatment period, if patients didn’t have at least one follicle with 18mm in diameter, excluded from this study. Results were analyzed using Repeat Measure test for quantity variable and square k for quality variable. Results: One hundred forty seven patients included in this study. Fifty patients were treated with clomiphene citrate for at least 4 consecutive cycles,19 patients 5cycles and7patients 6cycles.Analysis of data demonstrated that there was no difference in mean endometrial thickness in consecutive cycles of clomiphene citrate therapy. There was also no change in distribution of endometrial echo pattern in consecutive cycles of clomiphene citrate therapy. Conclusion: Considering the result, there is no additive harmful effect on endometrium with consecutive cycles of clomiphene citrate therapy.