P-155: Studies of Cytotoxic Effects ofCdSe Quantum Dots on Fetal Development Testis and Epididymis in Albino Mice

Background: Quantum dots (QDs) are among the most promising items in the nanomedicine toolbox. These nanocrystal fluorophores have several potential medical applications including nanodiagnostics, imaging, targeted drug delivery, Nevertheless, in vivo cytotoxicity of these nanoparticles has not been highly considered. For this reason, the cytotoxic effects of CdSe QDs on testis and epididymis embryonic development are presented in this study. Materials and Methods: In this work, 10, 20 and 40 mg/kg doses of CdSe QDs were injected to some female mice in in day 8 gestation. Structural and optical properties of QDs were studied by XRD, UV-Vis absorption spectrum and Scanning Tunneling Microscopy, and the number of cells in seminiferous tubes of various groups were analyzed using SPSS 16 programme (one way Anova test). Results: Histological studies of testis tissue in adult offspring didn’t show any effect of QDs on morphology seminiferous tubular, lamina propria, Interstitial tissue, germinal layer thickness and in number of spermatogonia, spermatocytes. Histological study of epididymis tissue also showed no significant effect of QDs on morphology and structure of tube and in the lumen content. Conclusion: This study showed no significant effect of QDs on embryonic development of testis and epididymis tissues, even in hight doses and considering lack of literature review in this field. This study can be an introduction to researches of toxicity effect of QDs on development of male reproduction system.