O-28: High Maternal Hemoglobin Concentration and Preeclampsia

Background: High maternal hemoglobin concentration has been increasingly linked to poor pregnancy outcomes in recent years. This study was aimed to determine whether high maternal hemoglobin (Hb) in first trimester is associated with preeclampsia. Materials and Methods: In 2009 a retrospective study was conducted and demographic and obstetric records of 1513 low risk pregnant mother registered to a staterun hospital in Tehran were studied. The association between first trimester hemoglobin concentration, BMI, Pregnancy weight gain, maternal age, and parity supplementation with calcium and/or multivitamin and preeclampsia was assessed in multiple logistic regression model. Results: The mean age of the studied mothers was 26.4 ± 5.2 years. 54.1% of sample were nulliparous and 44.1% had a BMI > 25 kg/m2, mean Hb concentration was 12.5 ± 1.1 g/dl. 5.6% of pregnancies were complicated by Preeclampsia. Results of binary logistic regression analysis showed that Hb concentration greater than 13.2g/dl (OR: 1.73, 95% IC: 1.07-2.81), BMI (OR: 1.58, 95% IC: 1.17-2.12) and calcium supplementation (OR: 0.38, 95% IC: 0.22-0.64) were significantly associated with preeclampsia. Conclusion: Our findings suggest that high Hb in the first trimester is related to subsequent preeclampsia. Prophylactic iron supplementation may increase the risk of adverse pregnancy outcomes when mother does not have iron deficiency or IDA, therefore routine iron administration to women with high Hb values might be modified.