O-15: Advanced Age Women and Miscarriage Rate

Background: Study question: what is the effect of advanced aged in pregnant women using assisted reproductive technology on the rate of miscarriages? Summary answer: the advanced age effects on the rate of miscarriages. What is known already: It is well known that miscarriage risk increases with age. The proportion of women giving birth after 35 years of age has risen considerably in developing countries. Several studies have concluded that women aged ≥35 years have a higher frequency of spontaneous abortion, than do younger women. Maternal age especially in women using ART is associated with adverse pregnancy outcomes, but the extent of effect is not clear. The aim of this study was to evaluate the relationship between the use of assisted reproductive technology and the incidence risk of abortion in advanced aged women. Materials and Methods: A retrospective approach was chosen to analyze the data of women who referred to Royan Institute from 24 October 2009 to 20 September 2012. In general, this study examined 4,082 women over 3 years. In this study pregnancy outcome of women less than 35 years and over 35 years were compared. Chi-square and logistic regression were used to statistical analysis. Results: The results showed for each year increase in women’s age, the odds of late abortion, missed abortion, early abortion less than 12 weeks and recurrent abortion increased by 1.06, 1.06, 1.04 and 1.12 times respectively.Limitations, reasons for caution: In this investigation there might be some source of uncertainty in the method used to calculate the outcomes. Some of outcomes might not be registered or some cases may be disconnecting their relationship with the clinic and this was out of researcher reach. Conclusion: Advanced age of pregnant women using ART effects on miscarriage rate.