Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines

نویسنده

  • Abdolhassan Doulah Department of Nursing, Faculty of Nursing and Midwifery, Islamic Azad University, Ahvaz Branch, Ahvaz, Iran
چکیده مقاله:

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.

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Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted withsecondary amines in boiling ethanol to afford the related 7-amino derivatives.

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عنوان ژورنال

دوره 4  شماره 2

صفحات  1- 7

تاریخ انتشار 2014-09-01

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