Nitric oxide in the nucleus raphe magnus modulates cutaneous blood flow in rats during hypothermia

نویسندگان

  • Ali Jahanshahi Department of Physiology, Tarbiat Modares University, Tehran, Iran
  • Alireza Komaki Department of Physiology, Hamedan University of Medical Sciences, Hamedan, Iran
  • Behnam Jamei Department of Basic Sciences, Allied Medical College, Iran University of Medical Sciences, Tehran, Iran
  • Javad Mirnajafi zade Department of Physiology, Tarbiat Modares University, Tehran, Iran
  • Mahmood Amiri Department of Physiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Masoumeh Kourosh Arami Department of Basic Sciences, Allied Medical College, Iran University of Medical Sciences, Tehran, Iran|Medical College of Saveh, Saveh University of Medical Sciences, Saveh, Iran
  • Sara Mehrpooya Department of Basic Sciences, Allied Medical College, Iran University of Medical Sciences, Tehran, Iran
چکیده مقاله:

Objective(s): Nucleus Raphe Magnus (NRM) that is involved in the regulation of body temperature contains nitric oxide (NO) synthase. Considering the effect of NO on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. Materials and Methods: To this end, tail blood flow of male Wistar rats was measured by laser doppler following the induction of hypothermia. Results: Intra-NRM injection of SNP (exogenous NO donor, 0.1- 0.2 μl, 0.2 nM) increased the blood flow. Similarly, unilateral microinjection of glutamate (0.1- 0.2 μl, 2.3 nM) into the nucleus increased the blood flow. This effectof L-glutamate was reduced by prior intra NRM administrationof NO synthase inhibitor NG-methyl-L-arginine or NG-nitro-L-argininemethyl ester (L-NAME, 0.1 µl, 100 nM). Conclusion: It is concluded that NO modulates the thermoregulatory response of NRM to hypothermia and may interactwith excitatory amino acids in central skin blood flow regulation.

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nitric oxide in the nucleus raphe magnus modulates cutaneous blood flow in rats during hypothermia

objective(s): nucleus raphe magnus (nrm) that is involved in the regulation of body temperature contains nitric oxide (no) synthase. considering the effect of no on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. materials and methods: to this end, tail blood flow of male wistar rats was measured by laser doppler following the induction of ...

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Reversible Inactivation and Excitation of Nucleus Raphe Magnus Can Modulate Tail Blood Flow of Male Wistar Rats in Response to Hypothermia

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reversible inactivation and excitation of nucleus raphe magnus can modulate tail blood flow of male wistar rats in response to hypothermia

background: the nucleus raphe magnus (nrm) is involved in thermoregulatory processing. there is a correlation between changes in the firing rates of the cells in the nrm and the application of the peripheral thermal stimulus. introduction: we examined the effect of reversible inactivation and excitation of nrm on mechanisms involved in tail blood flow (tbf) regulation in hypothermia. methods: h...

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Reversible inactivation and excitation of nucleus raphe magnus can modulate tail blood flow of male Wistar rats in response to hypothermia.

BACKGROUND The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus. INTRODUCTION we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail blood flow (TBF) regulation in hypothermia. METHODS ...

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عنوان ژورنال

دوره 18  شماره 10

صفحات  989- 992

تاریخ انتشار 2015-10-01

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