Myocardial fibrosis delineation in late gadolinium enhancement images of Hypertrophic Cardiomyopathy patients using deep learning methods

Late gadolinium enhancement score (LGE-Score) for prediction of extensive late gadolinium enhancement in hypertrophic cardiomyopathy

Late gadolinium enhancement score (LGE-Score) for prediction of extensive late gadolinium enhancement in hypertrophic cardiomyopathy Raymond H Chan, Barry J Maron, Iacopo Olivotto, Gabriele Egidy Assenza, Tammy S Haas, John R Lesser, Christiane Gruner, Andrew Crean, Harry Rakowski, James E Udelson, Ethan J Rowin, Massimo Lombardi, Franco Cecchi, Benedetta Tomberli, Paolo Spirito, Francesco Form...

Exuberant Pattern of Late Gadolinium Enhancement in Hypertrophic Cardiomyopathy

Patient aged 42, Caucasian, asymptomatic, with family history of HCM and diagnosis of the same cardiomyopathy 22 years ago. The 24-h Holter heart rhythm monitoring (April 5, 2012) showed sinus rhythm, rare atrial ectopic beats, presence of 2,970 isolated ventricular extrasystoles and five outbreaks of non-sustained ventricular tachycardia (NSVT), the longest one presenting 13 QRS complexes. Giv...

Quantitative analysis of late gadolinium enhancement in hypertrophic cardiomyopathy

BACKGROUND Cardiovascular magnetic resonance (CMR) with the late gadolinium enhancement (LGE) technique allows the detection of myocardial fibrosis in Hypertrophic cardiomyopathy (HCM). The aim of this study was to compare different methods of automatic quantification of LGE in HCM patients. METHODS Forty HCM patients (mean age 48 y, 30 males) and 20 normal subjects (mean age 38 y, 16 males) ...

[What is late gadolinium enhancement in hypertrophic cardiomyopathy?].

Hypertrophic cardiomyopathy (HCM) is a condition that can be defined in three ways: genetically, as caused by sarcomeric protein mutations; phenotypically by the presence of unexplained hypertrophy in the absence of afterload; and histologically by myocardial fibrosis, disarray, and small vessel disease. All these definitions have problems: only around half of HCM cases have an identifiable mut...

Bio-imaging: late gadolinium enhancement in hypertrophic cardiomyopathy and its relation to novel biomarkers of fibrosis

Background Late gadolinium enhancement (LGE) accurately detects myocardial fibrosis in hypertrophic cardiomyopathy (HCM), which has been recently shown to be an independent risk factor for cardiac events in this setting. Endoglin is an accessory protein for the TGF-b receptor, which stimulates myocardial fibrosis through modulating the response to Angiotensin II. We sought to explore the relati...

Improved prediction of adverse events in hypertrophic cardiomyopathy with quantitative late gadolinium enhancement and myocardial strain