Morphologic Variation in the Osteopetrotic Op/Op Mouse Skeleton

SUMMARY This study is designed to confirm the changes of various bones in the osteopetrotic op/op mouse. The female adult mouse were sonicated in papain solution. After the complete treatment, the bones (Skull, Mandible, Scapula, Humerus, Radius, Ulna, Hip, Femure, Tibia, Atlas, Axis and 5th Lumbar vertebra) were measured three dimensionally using of high quality scale and low power binocular microscope. The bones were then photographed and studied by Scanning Electron Microscope. The results revealed that the length of Jong bones are suppressed,the width are enlarged and the trabecular bones were very thickend and voluminous in compared with control group. We came to conclusion that,osteopetrosis inhibit the endocondral ossification with less effect on the intermembranous ossification.