Molecular markers as an indicator in the malignant potential of oral lichen planus: A systematic review

Molecular Markers of Oral Lichen Planus

Suitability/unsuitability of cell proliferation as an indicator of malignant potential in oral lichen planus: an immunohistochemical study.

BACKGROUND Oral lichen planus (OLP) is categorized as premalignant lesion although its malignant potential is a matter of controversy. The objective of this study was to investigate Ki67 expression in OLP, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS Expression of Ki67 was evaluated through immunohistochemistry (IHC) in groups of A (17 cases of epit...

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Background and Aim: Oral lichen planus (OLP) is a chronic, inflammatory, T-cell-mediated autoimmune oral mucosal disease. Oral lichenoid lesions develop as a type IV hypersensitivity reaction. Both of these entities are potential precancerous conditions; this adds to their clinical significance. The purpose of this literature review was to detect the similarities and the differences of these le...

Malignant transformation of oral lichen planus.

AIMS To investigate the malignant potential of oral lichen planus (OLP), a common mucocutaneous disease of unknown aetiology. The malignant potential of OLP is still controversial, with studies reporting malignant transformation rates of between 0 and 5.6%. We also aimed to identify factors that might be associated with malignant transformation. METHODS We retrospectively reviewed the records...

Oral lichen planus: malignant transformation and human papilloma virus: a review of potential clinical implications.

Oral lichen planus (OLP) occurs in from 2% to 3% of the population and may have a risk of malignant transformation into squamous cell carcinoma (SCC). This risk is not necessarily associated with exposure to tobacco and alcohol. An increased awareness of a possible role of human papilloma virus (HPV) and SCC led us to review a possible association between this virus infection and malignant tran...

Malignant potential of oral lichen planus an analysis of literature over the past 20 years

Aim: The study evaluates and compares the rate of malignant transformation in OLP and OLL and the relevance of initial diagnosis of dysplasia as reported in available literature, since 1995. Method: An electronic search of literature for retrospective and prospective studies of OLP was performed in the Pub Med MEDLINE database from 1995 to 2014. A total of 38 studies were included for the analy...