Memory and Motor Coordination Improvement by Folic Acid Supplementation in Healthy Adult Male Rats
نویسندگان
چکیده مقاله:
Objective(s)Previous studies have shown that vitamin B as well as folate supplementation has been implicated in cognitive and neurodegenerative disorders including Alzheimer’s and Parkinson's diseases. The aim of present study was to evaluate the effects of folic acid on passive avoidance task and motor coordination in healthy adult male rats.Materials and MethodsAnimals were randomly divided into five groups with 10 in each. 1) Sham treated (Veh); received same volume of normal saline as folate vehicle, 2-5) Test groups; each received a single dose of folate (5, 10 and 15 mg/ml/kg, IP daily for one week). At the end of the treatment with folic acid or vehicle, motor coordination in rotarod (after 24 hr) and passive avoidance memory in shuttle box (after 2 and 30 days) were evaluated, respectively.ResultsThe results showed that folic acid (5, 10, and 15 mg/kg) increased short-term (P
منابع مشابه
memory and motor coordination improvement by folic acid supplementation in healthy adult male rats
objective(s)previous studies have shown that vitamin b as well as folate supplementation has been implicated in cognitive and neurodegenerative disorders including alzheimer’s and parkinson's diseases. the aim of present study was to evaluate the effects of folic acid on passive avoidance task and motor coordination in healthy adult male rats.materials and methodsanimals were randomly divi...
متن کاملMaternal protein restriction with or without folic acid supplementation during pregnancy alters the hepatic transcriptome in adult male rats.
Feeding pregnant rats a protein-restricted (PR) diet induces altered expression of candidate genes in the liver of the adult offspring, which can be prevented by supplementation of the PR diet with folic acid (PRF). We investigated the effect of maternal nutrition during pregnancy on the liver transcriptome in their adult male offspring. Pregnant rats were fed control, PR or PRF diets. Male off...
متن کاملSpatial Memory, Motor Coordination, Cerebellar and Hippocampal Histoarchitectural Changes following Atropine Administration to Adult Mice
Atropine is a non-selective muscarinic receptor antagonist. In overdoses, atropine is poisonous. It is sometimes added to potentially addictive drugs, particularly anti-diarrhoea opioid drugs such as diphenoxylate or difenoxin. The aim of this study was to investigate spatial memory and motor changes associated with varying doses (5 and 10 mg/kg body weight) ingestion of atropine, as well as it...
متن کاملEffect of Folic Acid on serum Leptin, Grehlin concentration, and feed intake in male Wistar rats
Introduction: There is no comprehensive study on the effect of Folate on food intake therefore the present study was carried out to determine the effect of Folate supplementation on serum concentrations of Leptin and Grehlin and food intake in male Wistar rats. Methods: The study was carried out for 42 days during which the animals were weighed weekly their food and water intakes were measu...
متن کاملVentricular remodeling induced by retinoic acid supplementation in adult rats.
Retinoic acid (RA) plays a role in regulating cardiac geometry and function throughout life. The aim of this study was to analyze the cardiac effects of RA in adult rats. Wistar rats were randomly allocated to a control group (n = 18) receiving standard rat chow and a group treated with RA (n = 14) receiving standard rat chow supplemented with RA for 90 days. All animals were evaluated by echoc...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 15 شماره 6
صفحات 1173- 1179
تاریخ انتشار 2012-11-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023