Melkersson-Rosenthal syndrome: Appropriate response to the combination treatment with intralesional triamcinolone injection and oral azithromycin
نویسندگان
چکیده مقاله:
Melkersson-Rosenthal syndrome is an uncommon disorder which is presented by a triad of lip swelling, facial nerve palsy, and a fissured tongue. A number of treatments have been reported for this syndrome with variable outcomes. We have reported a 38-year-old female patient with lower lip swelling and a fissured tongue on clinical examination. She was also suffering from facial nerve paralysis since 8 years ago. A significant improvement of the signs was achieved with a combination of intralesional corticosteroid injection and oral azithromycin. Although our patient showed the triad, she had an atypical clinical course due to the initiation of syndrome with facial nerve palsy, resulting in a delay in definite diagnosis of her disease. The anti-inflammatory and immuno-modulatory effects of azithromycin and the therapeutic properties of the intralesional injection of corticosteroid have an important role in managing this syndrome.
منابع مشابه
Cheilitis granulomatosa of Melkersson-Rosenthal syndrome: treatment with intralesional corticosteroid injections.
BACKGROUND Melkersson-Rosenthal syndrome may manifest as the classical triad (orofacial edema, facial nerve palsy and stable lingua plicata) but monosymptomatic manifestations or combinations of typical symptoms are not infrequent. The available therapeutic options provide only limited success or temporary benefit. CASE REPORT A 20-year-old man presented with a 7-month history of recurrent ep...
متن کاملMelkersson-Rosenthal syndrome
Key points • Melkersson-Rosenthal syndrome should be suspected in cases of recurrent facial palsy associated with swelling of orofacial structures and/or a furrowed tongue. • Biopsy of suggestive lesions typically reveals noncaseating granulomas with perivascular and lymphatic inflammatory cell infiltration. • The pathophysiology involves an immunologically mediated inflammatory response. • Tre...
متن کاملSyndrome de Melkersson-Rosenthal
Le syndrome de Melkersson-Rosenthal est une entité rare. Dans sa forme complète, il se caractérise par un œdème cutanéo-muqueux de la face, une paralysie faciale périphérique récidivante et une langue plicaturée. Il peut poser un problème diagnostique dans sa forme incomplète. Son traitement est essentiellement médical, parfois chirurgical. Femme âgée de 58 ans, diabétique et hypertendue, a con...
متن کاملOral Crohn's disease: the distinction from the Melkersson-Rosenthal syndrome.
Orofacial swelling, particularly of the lips, tongue, buccal mucosa and gingiva is a feature of the localised granulomatous condition known as the MelkerssonRosenthal syndrome,1 but may also represent oral manifestations of chronic inflammatory conditions, including Crohn's disease2 or sarcoidosis.3 Oral manifestations of these systemic conditions may precede involvement in other areas by sever...
متن کاملCheilitis granulomatosa associated with Melkersson-Rosenthal syndrome.
Melkersson-Rosenthal syndrome (MRS) consists of persistent or recurrent orofacial edema, relapsing facial palsy and fissured tongue. The complete triad of symptoms is uncommon, varying from 8 to 25%. The presentation of only one symptom is more common. The most frequent complaint is facial edema and enlargement of the lips. We describe a case of a 17-year-old Brazilian girl with limited edema o...
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عنوان ژورنال
دوره 18 شماره 3
صفحات 140- 143
تاریخ انتشار 2015-07-01
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