Level of Interferon Gamma in the Blood of Tuberculosis Patients

نویسندگان

  • Khursheed Javaid Department of Immunology
  • Muhammad Ikram Ullah Biochemistry department
  • Saleem-Uz -Zaman Department of Pulmonary Medicine,Shalamar Hospital, Lahore, Pakistan
  • Shahid Hussain Department of Physiology and Cell Biology
  • Tanveer Ahmad Histopathology department, University of Health Sciences, Lahore, Pakistan
چکیده مقاله:

Background: Interferon gamma (IFN-γ), a cytokine produced by a variety of cells is involved in the immune response against M. tuberculosis. It activates the production of other cytokines and molecules that kill mycobacterium. IFN-γ also has diagnostic role in identification of active and latent tuberculosis. Objective: To determine the level of IFN-γ in the blood of TB patients. Methods: Ninety-one subjects were selected, including 54 active TB patients and 37 healthy controls. Among 54 TB patients, 27 had confirmed TB and 27 were clinically diagnosed as having TB. IFN-γ concentration was determined in their blood by an ELISA technique. Results: In TB patients, Mean + SD of IFN-γ was 48.69 + 28.78 pg/ml while it was 12.99 + 5.70pg/ml in the control group (p

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level of interferon gamma in the blood of tuberculosis patients

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عنوان ژورنال

دوره 7  شماره 4

صفحات  240- 246

تاریخ انتشار 2010-12-01

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