Leukocyturia, another clue to inflammation in acute coronary syndrome

Introduction: Cronary artery disease is the main cause of mortality in developed countries. Classic risk factors have not been able to explain epidemiologic variants in this disease, hence other risk factors including systemic infections are under survey. This study was designed to evaluate the possible role of local and systemic infections in producing acute coronary syndrome (ACS). Methods: This prospective case-control study was conducted on all patients admitted with ACS diagnosis (unstable angina, myocardial infarction) in CCU ward of Fatemieh hospital, Semnan. The control group was selected among those patients admitted to internal ward due to noninfectious disease. Overall 200 cases and 200 controls entered the survey. Leukocyturia, hematuria and urine culture results were obtained and compared. SPSS software, t-test and Chi-square test were used for data analysis and P<0.05 was considered significant. Results: The case and control groups had no significant difference considering age and sex. Mean age of cases and controls were 60.03&plusmn;19.32 and 59.9&plusmn;17.2 years, respectively. Hematuria was seen in 18.5% of cases and 5% of control group (P<0.0001). Albuminuria was seen in 6% of cases and 7% of controls which was not a meaningful difference. Conclusion: The results show that evidences of mild urinary tract infection such as leukocyturia and hematuria are seen more prevalent in patients with ACS than control group. This can be a clue to a mild underlying inflammation, infection due to uncommon microorganisms or leukocyturia and hematuria during a systemic infectious process. &nbsp;