Is There any Mean to Postpone The Menopausal Ovarian Senescence?

The ovarian reserve (OR) gradually decreases throughout the female fertile life. This continuous depletion in OR is irreversible. This occurs through a programmed cell death known apoptosis. Some factors hasten such depletion such as chemo- and radiotherapy. Others have been investigated in trials to preserve the OR including gonadotropins, cytokines, growth hormones, nitric oxide and reorganization of the actin cytoskeleton. The loss of ovarian reserve occurs normally at the menopausal age, a stage called menopausal ovarian senescence. At some periods, there are other sources for ovarian hormones away from the ovary such as during use of contraceptive pills and at pregnancy after the formation of the placenta. Future trials to preserve the ovarian follicles at these periods might postpone the onset of the menopause and hence lengthen the fertile female age.