Insensitivity to pain due to Genetic Mutation
نویسندگان
چکیده مقاله:
Pain is neuroanatomically, psychologically and neurophysiologically complicated and its first function is protecting all alive creature body. This issue is so questionable and interesting that people who don’t feel pain how face this sensation and what problems threaten them. So many researchers by using 73 references, articles from electronical and library references have done a clinical study about CIPA which is a rare disorder of neuropathic disorders. These patients have no sensation toward pain and paiful stimulations and no sweating. This disorder has been occurred by genetic mutation and has been under study from 1996 to 2012. Which un health – care tream can reduce their complications by early diagnosis and thereaputic and preventive interventions.
منابع مشابه
Orthopedic aspects of familial insensitivity to pain due to a novel nerve growth factor beta mutation.
BACKGROUND Congenital insensitivity to pain is a rare hereditary sensory neuropathy. PATIENTS We present 6 patients from a family with a mutation in the nerve growth factor beta gene (NGFB). RESULTS 3 patients were homozygous with a mutilating arthropathy starting early in life, and 3 patients were presumably heterozygous with a milder course starting in adulthood. All patients had normal m...
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Congenital insensitivity to pain with anhidrosis is a rare disease of the nervous system which causes one to lose his/her feeling of pain. The disease is subtype four of hereditary sensory and autonomic neuropathy (HSAN IV) that results from NTRK1 gene defect. Direct sequencing was performed to screen NTRK1 for mutations. The result revealed a homozygous deletion of adenine on intron 14 that ma...
متن کاملNorrbottnian congenital insensitivity to pain.
Congenital insensitivity to pain is a rare hereditary neuropathy. We present patients from a large family in Norrbotten, Sweden with a mutation in the nerve growth factor beta gene (NGFbeta). Using a model of recessive inheritance, we identified an 8.3-Mb region on chromosome 1p11.2-p13.2 shared by the affected individuals in the family. Analysis of candidate genes in the disease-critical regio...
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Congenital insensitivity to pain with anhydrosis (CIPA) is a rare genetic disorder characterized by inability to feel pain and temperature, and decreased or absent sweating. Familiarity to this condition is important to avoid misdiagnosing it with leprosy and other peripheral nerve diseases. An inability to feel pain may lead to repeated self-trauma (tongue, lips and finger tips) ultimately lea...
متن کاملCongenital insensitivity to pain. Orthopaedic manifestations.
We reviewed 13 patients with congenital insensitivity to pain. A quantitative sweat test was carried out in five and an intradermal histamine test in ten. DNA examination showed specific mutations in four patients. There were three clinical presentations: type A, in which multiple infections occurred (five patients); type B, with fractures, growth disturbances and avascular necrosis (three pati...
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Investigators from New York University, NY, studied 14 patients with congenital insensitivity to pain with anhidrosis (CIPA), compared to 10 patients with chronically deficient sympathetic activity (pure autonomic failure), and 15 normal age-matched controls.
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عنوان ژورنال
دوره 18 شماره None
صفحات 337- 345
تاریخ انتشار 2014-10
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