Increased Expression of Two Alternative Spliced Variants of CD1d Molecule in Human Gastric Cancer

نویسندگان

Abolghasem Ajami Department of Immunology, School of Medicine | Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari

Mohsen Tehrani Department of Immunology, School of Medicine | Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari

Nasim Hafezi Department of Immunology, School of Medicine

Reza Alizadeh-Navaei Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari

Touraj Farazmandfar School of Advanced Medical Science Technologies, Golestan University of Medical Sciences, Gorgan

Vahid Hosseini Inflammatory Diseases of Upper GI Tract Research Center, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran

چکیده مقاله:

Background: CD1d presents glycolipid antigens to invariant natural killer T (iNKT) cells. The role of CD1d in the development of peptic ulcer and gastric cancer has not been revealed, yet. Objective: To clarify the expression of alternatively spliced variants of CD1d in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), and gastric cancer (GC), according to their endoscopic and histopathological examinations. H. pylori infection was diagnosed by rapid urease test and histopathology. The expression levels of V2, V4, and V5 spliced variants of CD1d molecule were determined by quantitative Reverse Transcriptase PCR. Results: Relative gene expression levels of V4 were higher in GC patients (n=37) than those in NUD (n=49) and PUD (n=51) groups (p

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increased expression of two alternative spliced variants of cd1d molecule in human gastric cancer

background: cd1d presents glycolipid antigens to invariant natural killer t (inkt) cells. the role of cd1d in the development of peptic ulcer and gastric cancer has not been revealed, yet. objective: to clarify the expression of alternatively spliced variants of cd1d in peptic ulcer and gastric cancer. methods: patients with dyspepsia were selected and divided into three groups of non-ulcer dys...

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