Idiopathic Hypereosinophilic Syndrome

The idiopathic hypereosinophilic syndrome.

A 14 year old girl with idiopathic hypereosinophilic syndrome is described. In addition to weight loss, anaemia, amenorrhoea, general lethargy, anorexia, mouth ulcers, blisters of hands and feet, and petechial skin rash, she had features of involvement of the cardiovascular system as the major complication. She responded well to treatment. After a comprehensive search of the published reports 1...

The idiopathic hypereosinophilic syndrome.

The idiopathic hypereosinophilic syndrome.

Idiopathic hypereosinophilic syndrome (HES) is empirically defined as the presence of prolonged eosinophilia without an identifiable underlying cause, and with evidence of end-organ dysfunction. Virtually any organ system may be involved, most frequently the heart, the central and peripheral nervous system, the lungs and the skin. We report on two clinical cases where the diagnosis of HES, with...

Cerebral arteriolar thromboembolism in idiopathic hypereosinophilic syndrome.

OBJECTIVE To describe imaging findings as well as postmortem brain and cardiac pathology in a patient with fulminant idiopathic hypereosinophilic syndrome. DESIGN Case report. SETTING University hospital. PATIENT A 48-year-old right-handed man with hypereosinophilia, rapidly progressive encephalopathy, and focal neurological deficits who died 22 days after presentation. MAIN OUTCOME MEA...

Idiopathic hypereosinophilic syndrome with skull base involvement.

Idiopathic hypereosinophilic syndrome (HES) is a heterogeneous disorder characterized by prolonged eosinophilia without an identifiable cause, ultimately resulting in organ dysfunction. Three major types of neurologic involvement have been well defined in HES; however, to our knowledge, inflammatory pseudotumor (IPT) in association with HES has not been reported. We present a case of IPT of the...

Loeffler’s Endocarditis due to Idiopathic Hypereosinophilic Syndrome

Introduction Hypereosinophilic syndrome (HES) is a rare disease characterized by persistent eosinophilia (>1,500 eosinophils× 10/L) for at least 6 months that remains unexplained in spite of a comprehensive evaluations and evidence of organ dysfunction primarily attributed to the eosinophilia. Loeffler’s endocarditis is a myocardial disease, thought to be secondary to idiopathic hypereosinophil...