I-13: The Domestic Hen as Model to Studies Ovarian Cancer
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Ovarian tumors of the hen.
Present available information regarding ovarian tumors in hens is incomplete in most aspects, and this lack of knowledge hampers use of hens as models for study of ovarian cancer. A study of 466 hens ranging from 2 to 7 years of age and covering a period of more than 3 years has provided much needed information relative to reproductive tract neoplasia. On the basis of this study, it is apparent...
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Ovarian cancer is the leading cause of death due to gynecologic cancer in the United States and the fifth leading cause of cancer death among US women. Currently, only 15% of cases are diagnosed at an early stage. If ovarian cancer is detected and treated early, the five-year survival rate is greater than 90% [1]. The fact that most ovarian cancers are diagnosed at later stages illustrates our ...
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This perspective on Romero et al. (beginning on p. 792 in this issue of the journal) discusses the available animal models of ovarian cancer, including the laying hen, non-human primate, and transgenic rodent models, and their relevance to ovarian cancer chemoprevention studies.
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Recent advances in the technology of vitrification of human oocytes and embryos have increased the opportunities for fertility preservation in cancer patients. Ovarian stimulation in this group of patients is associated with some unique challenges. A controversy in this field rotated around the hypothesis that the transient elevations of estrogen during an IVF cycle may stimulate tumor growth; ...
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Cancer is not uncommon and no longer considered to be an incurable disorder. 10% of cancer cases occur under the age of 45. There is a remarkable improvement in treatment and survival rates. Today women have been delaying initiation of childbearing because the incidence of most cancers increases with age. Delayed childbearing results in more female cancer survivors. As a consequence there is an...
متن کاملThe hen model of human ovarian cancer develops anti-mesothelin autoantibodies in response to mesothelin expressing tumors
OBJECTIVE Study of the hen immune system led to seminal contributions to basic immunological principles. Recent studies of spontaneous ovarian cancer in the laying hen show strikingly similar tumor types and antigen expression compared to human ovarian cancer, suggesting hens would be valuable for studies of tumor immunology and pre-clinical vaccine development. Circulating mesothelin is a rela...
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عنوان ژورنال
دوره 9 شماره 2
صفحات 13- 13
تاریخ انتشار 2015-09-01
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