Ghrelin associate determinative markers of fasting blood glucose in none diabetic healthy obese males

Introduction: Ghrelin, a gut neuropeptide, plays an important role in appetite, food intake and weight regulation. The aim of the present study was to determine serum ghrelin in relation to fasting glucose concentration and effective markers in glucose level (insulin, insulin resistance, beta- cell function) in none-diabetic obese males. Methods: We studied the baseline glucose, serum insulin and ghrelin concentration in 45 none diabetic adult obese males aged 36-49 years that randomly participated in the study. Blood sampling was obtained between 8 to 9 o'clock after an overnight fasting. Insulin resistance and beta- cell functional indexes were calculated by fasting glucose and insulin by HOMA formula. Association between serum ghrelin with glucose and the other glucose determinative markers were determined by liner regression analysis. Results: Liner regression analysis showed that serum ghrelin were not related with glucose, insulin and insulin resistance in all subjects. Serum ghrelin level was linearly correlated but not significant with beta- cell function. Conclusion: Despite abundance evidence of closely relation between ghrelin and fasting glucose level in obese diabetic patients, the present study state that serum ghrelin level is not correlated with glucose and another effective variables in glucose concentration in none-diabetic subjects. It seems that the relation between ghrelin with the variables is more evident in obese diabetic than in none obese diabetic.