Genetic Drifts in PKR-EIF2A Phosphorylation Homology Domain Region in Iranian HCV Positive Patients during Interferon Therapy
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Interferon Resistance of Hepatitis C Virus Genotypes 1a/1b: Relationship to Structural E2 Gene Quasispecies Mutations
Hepatitis C virus (HCV) envelope glycoprotein-2 (E2) inhibits the interferon (IFN)–induced, double –stranded RNA activated protein kinase (PKR) via PKR eukaryotic initiation factor-2α phosphorylation homology domain (PePHD). Present study examined the genetic variability of the PePHD in patients receiving interferon therapy. The PePHD region from HCV genotype 1a/1b infected patients receiving I...
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hepatitis c virus (hcv) envelope glycoprotein-2 (e2) inhibits the interferon (ifn)–induced, double –stranded rna activated protein kinase (pkr) via pkr eukaryotic initiation factor-2α phosphorylation homology domain (pephd). present study examined the genetic variability of the pephd in patients receiving interferon therapy. the pephd region from hcv genotype 1a/1b infected patients receiving i...
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Interferon alpha (IFNα) therapy, despite good efficacy in curing HCV infection, leads to major side effects, in particular inducement of a strong peripheral T-cell lymphocytopenia. We here analyze the early consequences of IFNα therapy on both thymic function and peripheral T-cell homeostasis in patients in the acute or chronic phase of HCV-infection as well as in HIV/HCV co-infected patients. ...
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عنوان ژورنال
دوره 2 شماره None
صفحات 6- 12
تاریخ انتشار 2008-02
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