Formulation and Evaluation of Extended- Release Tablet of Zolpidem Tartrate by Wet Granulation Technique
نویسندگان
چکیده مقاله:
The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4M) as release retardant, polyvinylpyrrolidone (PVP k30) as binder and Magnesium Stearate using Factorial design. In vitro release study ofmatrix tablets was carried out in 0.01N HCl for 2 hours. All prepared matrix tablets were evaluated forphysicochemical evaluation and drug content. The formulation that had release profile according to UnitedState Pharmacopoeia selected for stability study according to ICH guidelines
منابع مشابه
Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
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عنوان ژورنال
دوره 4 شماره 1
صفحات 35- 41
تاریخ انتشار 2016-06-19
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