Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy
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expression and distribution of calcium-binding protein s100p in human placenta during pregnancy
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متن کاملExpression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy
BACKGROUND S100P is a member of the S100 family of calcium-binding proteins, and it participates in pathophysiological events, such as tumor growth and invasion. Based on the striking similarities between trophoblast cells and tumor cells with regard to proliferative and invasive properties, we raised the question of whether and how S100P expresses in trophoblast cells during development. This ...
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The Ca2+-binding protein (HCaBP) of the human placenta was studied with respect to its biochemical properties, tissue and cellular distribution, and possible involvement in placental Ca2+ transport. Optimal Ca2+ binding by the HCaBP occurs at pH7-8 and in I00mM-Na+ and 3mM-Ca2+. The HCaBP possesses at least 10 Ca2+-binding sites with a Kd of 5 x 10-6M ([Ca2+]). Highly specific rabbit-derived an...
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عنوان ژورنال
دوره 8 شماره 4
صفحات 445- 452
تاریخ انتشار 2015-02-01
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