Elevated IL-17 and TGF-β Serum Levels: A Positive Correlation between T-helper 17 Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder

elevated il-17 and tgf-β serum levels: a positive correlation between t-helper 17 cell-related pro-inflammatory responses with major depressive disorder

introduction: depression is a mental disorder that highly associated with immune system. therefore, this study compares the serum concentrations of il-21, il-17, and transforming growth factor β (tgf-β) between patients with major depressive disorder and healthy controls. methods: blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls wi...

Elevated levels of anti inflammatory IL-10 and pro inflammatory IL-17 in malignant pleural effusions

BACKGROUND Pleural effusions can be caused by highly different underlying diseases and are characterized by complex interactions of various local and circulating cells as well as numerous soluble parameters like interleukins (IL). Knowledge of this complex network can be helpful in order to make the differential diagnosis in known malignant pleural effusions and understand the underlying immuno...

T-helper-17, Regulatory T-helper Cells Related Serum Markers and IL-13 in the Outcome of Polytraumatic Patients with Bacteremia

Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases

T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF- α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumato...

Increased IL-17 and TGF-β serum levels in peripheral blood of patients with β-thalassemia major: implication for continual transfusions role in T helper17-mediated proinflammatory responses.

BACKGROUND/AIM Recent studies have shown that IL-17-producing CD4+ T helper (Th17) cells play an important role in proinflammatory processes. In this report we analyzed IL-17, IL-21, and TGF-β serum levels in the peripheral blood of Iranian beta-thalassemia major patients that clinically exhibited splenectomy and iron overload. MATERIALS AND METHODS Blood samples were collected from 43 beta-t...