Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients with Staghorn Calculi Undergoing Percutaneous Nephrolithotomy: Randomized Controlled Trial
نویسندگان
چکیده مقاله:
Background: The incidence of renal hemorrhage during percutaneous nephrolithotomy (PCNL) is high. We sought to evaluate the effects of tranexamic acid (TXA) on bleeding and hemoglobin levels of patients with staghorn calculi treated with PCNL.Methods: In a double-blind clinical trial, 120 patients with staghorn calculi candidated for PCNL in Alzahra Hospital between January 2014 and November 2017, Isfahan, Iran, were classified into two groups in terms of the stone size (>4 cm and <4 cm). The patients in both groups were then randomly assigned to receive either 1 g of TXA intravenously or normal saline. (The generation of random numbers was done by computer.) Thus, there were four groups of 30 patients each. The transfusion rate, the mean volume of blood loss, the operative duration, and the hemoglobin level were compared between the intervention and control groups for each stone-size category. Statistical analysis was performed using SPSS, version 19. The paired and independent t test and the Pearson coefficient correlation were used, and a P value less than 0.05 was considered statistically significant.Results: The mean volume of blood loss was significantly higher in the control group patients than in those receiving TXA, in both stone-size categories (P<0.001). There was no significant difference in the postoperative hemoglobin level between the intervention and control groups, in both stone-size categories (P=0.26 and P=0.10, respectively). In addition, the mean volume of blood loss increased significantly with an increase in the operative duration (P<0.001). Conclusion: TXA reduced the risk of bleeding during and after PCNL and attenuated the drop in the hemoglobin level in the postoperative period. Longer operative procedures were associated with an increase in the bleeding volume. Trial Registration Number: IRCT20180209038673N1
منابع مشابه
Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients Undergoing Percutaneous Nephrolithotomy: Letter to Editor
متن کامل
Comparing Adrenaline with Tranexamic Acid to Control Acute Endobronchial Bleeding: A Randomized Controlled Trial
Background: Hemoptysis occurs due to either pulmonary diseases or bronchoscopy interventions. The aim of the present study was to compare the efficacy of the endobronchial instillation of adrenaline with that of tranexamic acid. Methods: Fifty patients were randomly selected as 2 double-blinded sample groups (n=25). In these patients, bleeding could not be controlled with cold saline lavage dur...
متن کاملTotally Tubeless Percutaneous Nephrolithotomy and Staghorn Calculi; a Mini-Review
Kidney stone is a common problem in population and had medical or surgical treatment. Surgery treatment had many technique, but now, Percutaneous Nephrolithotomy (PCNL) is a standard surgery care of renal calculi. In recent years, surgeons defined modification methods of PCNL such as tubeless PCNL and totally tubeless PCNL. These modified methods were associated with less complication, reduced ...
متن کاملrandomized controlled trial study about compare of post operative pain after milligan morgan versus submucosal hemorrhoidectomy with & without pudendal nerve marcaine block in patients that had hemorrhoidectomy in imam hossein hospital of shahrood in 1389-90
مقدمه:هموروئید یکی از شایعترین بیماریهای جراحی ناحیه آنورکتال است که با درد و خونریزی بروز می کند. کاهش دردبعد عمل علاوه بر افزایش رضایت بیمار باعث کاهش مدت بستری و کاهش بار تحمیلی بر روی اقتصاد جامعه می گردد. مطالعه حاضر مقایسه ای از لحاظ میزان درد و میزان تأثیر مارکائین به عنوان روشی برای پروفیلاکسی درد بعداز عمل،دو روش هموروئیدکتومی باز و بسته انجام می دهد. مواد وروشها: این مطالعه کارآزمایی...
comparing the effects of tranexamic acid and mefenamic acid in iud-induced menorrhagia: randomized controlled trial
background intrauterine device (iud) is a safe and efficient method for preventing pregnancy favored by many women. menorrhagia is the most common complication of using copper iud. we aimed to compare the effect of tranexamic acid and mefenamic acid on the reduction of copper iud-induced menorrhagia. methods in this randomized controlled trial, 84 women who were using iud (tcu-380) with complai...
متن کاملDoes tranexamic acid decrease bleeding in patients undergoing cardiopulmonary bypass?
We reviewed the records of 66 patients who underwent cardiopulmonary bypass; half of these patients received the plasmin inhibitor, tranexamic acid. The demographics were not different between the group who received tranexamic acid and the group who did not (control group). There was no difference in the heparin or protamine requirements between the two groups. There was a significantly greater...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 44 شماره 6
صفحات 457- 464
تاریخ انتشار 2019-11-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023