Effect of Troxerotin on permanent cerebral ischemia in male mice

Introduction: Stroke is a neurological disease and one of the leading causes of death all over the world. It is also an important cause of disability in people over age over 65. It may be possible to reduce the incidence of cerebral ischemia using antioxidants, followed by inhibition of oxidative and inflammatory mechanisms. Troxerutin is a natural bioflavonoid with antioxidant and anti-inflammatory properties. However, its neuroprotective effects have not yet been studied. The present study aimed to investigate the effect of troxerutin on ischemic brain damage in male mice. Materials and Methods: In this experimental study, 39 male mice (30-25 grams) were used. The animals were divided into three groups: 1. Sham group 2. Ischemic brain group 3. The ischemic brain group, receiving troxerutin drug. Cerebral ischemia was induced in the second and third groups of mice. Five hours later, group 3 received 300 mg/kg troxerutin intraperitoneal injection. After 24 and 48 hours, the effect of troxerutin on sensory and motor neurological disorders, cerebral edema, and infarct volume was investigated. Analysis of variance test was performed by SPSS software (21) using one-way and two-way. Results: The results indicated that troxerutin reduced stroke volume (p=0.05) and cerebral edema (p=0.05) compared with the control group. Troxerutin also improved sensory-motor function (p<0.0001) and balance function and muscle strength (p<0.05) Conclusion: Treatment with troxerutin can have beneficial effects on complications and disorders caused by cerebral ischemia.