Effect of Synbiotics on Lipid Profile and Serum Levels of Gonadotropins, Insulin and Glucose in Rats with Polycystic Ovary Syndrome Induced by Lipopolysaccharide

Background: In women of childbearing age, Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder. The cause of PCOS is still unknown and several factors may be involved. Objective: This study aims to evaluate the effect of synbiotics on serum parameters such as Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), triglyceride, cholesterol, glucose, and insulin in rats with PCOS. Methods: In this study, 40 adult female Wistar rats weighing approximately 180-200 g were randomly divided into five groups of control, PCOS, PCOS+LPS, PCOS+Synbiotic, PCOS+LPS+Synbiotic. To induce PCOS, rats were treated with Lipopolysaccharide (LPS) for 21 days. At the end, serum levels of LH, FSH, and insulin were measured by the ELISA method, and blood glucose, cholesterol, and triglyceride levels were measured by the enzymatic method. The results were analyzed in SPSS v. 22 software using one-way ANOVA and Tukey’s Post Hoc test. Results: The levels of triglycerides, cholesterol, insulin, glucose, FSH, and LH in the PCOS and PCOS+LPS groups were significantly higher compared to the control group (P<0.05). Treatment with synbiotics in the intervention groups caused a significant reduction in all variables (P<0.05). Conclusion: Synbiotics have beneficial effects on the improvement of lipid profile, gonadotropins, insulin, and glucose levels in PCOS rats induced by LPS.