Effect of Physiological noise on Thoraco-Lumbar spinal cord fMRI in 3T Magnetic field

نویسندگان

  • Ali Khatibi McConnel Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada
  • Amir Hossein Batouli Neuro-Imaging and Analysis Group (NIAG), Tehran University of Medical Sciences, Tehran, Iran.
  • Hamed Dehghani Department of Medical Physics and Biomedical engineering, Tehran University of Medical Sciences, Tehran, Iran, Neuro-Imaging and Analysis Group (NIAG), Tehran University of Medical Sciences, Tehran, Iran.
  • Mohammad Ali Oghabian Department of Medical Physics and Biomedical engineering, Tehran University of Medical Sciences, Tehran, Iran, Neuro-Imaging and Analysis Group (NIAG), Tehran University of Medical Sciences, Tehran, Iran.
چکیده مقاله:

Introduction: Functional MRI methods have been used to study sensorimotor processing in the brain and the Spinal cord. However, these techniques confront unwanted contributions to the measured signal from physiological fluctuations. For the spinal cord imaging, most of the challenges are consequences of cardiac and respiratory movement artifacts that are considered as significant sources of noise. Spinal cord in Thoraco-Lumbar is close to lungs and diaphragms that influence cerebrospinal fluid-filled spaces and cause changes in thesusceptibility due to the change in the amount of air in the lung. In this study, we investigatedthe effect of each source of physiological noise and contribution of them to the outcome ofthe analysis of the BOLD signal in human spinal cord during a sensory stimulation of the foot.   Materials and Methods: Fifteen young healthy male volunteers participated in the study. Sixty pressure pain stimuli delivered on L5 dermatome between the two malleoli. All of functional data were collected using a 3T Siemens Prisma scanner with 31 axial slices T2*-weighted ZOOMit (TR = 3000 ms; TE = 30 ms; FA = 90°; FoV = 160 × 160 mm; matrix size = 64 × 64). Respiratory and cardiac signals were recorded during the imaging session using the data acquired from theimplemented physiological monitoring unit. The Spinal Cord Toolbox and FSL were used forimage processing and analysis. Generated respiration and cardiac regressors were includedin the GLM for the quantification of the effect of each of them on the task-analyses results. The sum of activated voxels of the clusters in the spinal cord and in all the image was calculated.   Results: Comparison of sum of activated voxels. A one-way within subject’s ANOVA was applied toevaluate the effect of physiological functions on spinal cord fMRI in three noise correction inthe GLM. There was a statistically significant effect of physiological noise correctiononnumber of activated voxels in Image, F (3, 42) = 3.00689, p = .040817, η2 =0.17, and thisvalues in spinal cord was F(3, 42) = 21.314, p =.00001, , η2 =0.6. Bonferroni post hoc testsillustrate that cardiac noise correction had an effective role on increase activated voxels (mean = 23.46±9.46) compared to other noise correction methods.   Conclusion: The effect of the Heart-beat and Respiration movements has a significant role in thephysiological noise and concurrency between movements with task and correction of thismovements can remove the real effect of stimulation. Cardiac effect and changes in thecorrected results are higher than other physiological noise sources. In spite of previous work,displacement of the spinal cord and effect of this noise in the fMRI results are significant andcannot be ignored.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Physiological Noise on Thoraco-lumbar Spinal Cord FMRI in 3T Magnetic Field

Introduction: Functional MRI methods have been used to study sensorimotor processing in the Spinal cord. However, these techniques confront unwanted contributions to the measured signal from the physiological fluctuations. For the spinal cord imaging, most of the challenges are consequences of cardiac and respiratory movement artifacts that are considered as significant sources of noise, especi...

متن کامل

Investigation of the dose enhancement effect due to gold nanoparticles at 18 MV radiotherapy using MAGIC-f and Monte Carlo methods Thoraco-Lumbar spinal cord fMRI in 3T Magnetic field

Introduction: Normoxic MAGIC-f polymer gels are established dosimeters used for three dimensional dos uantifications in radiotherapy. The high atomic number nanoparticles such as gold are nov adiosensitizers used to enhance doses delivered to tumors. The aim of this study was t vestigate the effect of gold nanoparticles (GNPs) in enhancing percentage depth doses (PDD ithin the...

متن کامل

Spinal Cord Infarction Occurring during Thoraco-lumbar Sympathectomy.

The arterial blood supply of the spinal cord depends on a single anterior spinal artery and two posterior spinal arteries. The anterior spinal artery, which is the more important, commences within the cranial cavity by the union of the anterior spinal branches of each vertebral artery and subsequently is fed by several tributary arteries. Down the length of the spinal cord the anterior spinal a...

متن کامل

Physiological Noise in Brainstem fMRI

The brainstem is directly involved in controlling blood pressure, respiration, sleep/wake cycles, pain modulation, motor, and cardiac output. As such it is of significant basic science and clinical interest. However, the brainstem's location close to major arteries and adjacent pulsatile cerebrospinal fluid filled spaces, means that it is difficult to reliably record functional magnetic resonan...

متن کامل

Implementation of Axial Diffusion Tensor Imaging in the Lumbar Spinal Cord at 3T

Introduction: Spinal diffusion tensor imaging (DTI) is limited by severe motion artefacts and a low signal-to-noise ratio (SNR). Current gradient coils, with low-eddycurrent designs, open the field for the usage of monopolar Stejskal-Tanner sequences [1]. With these schemes, smaller echo times and therefore a higher SNR can be achieved. Only a few studies of lumbar spinal DTI in humans already ...

متن کامل

Assessment of spinal movement reduction by thoraco-lumbar-sacral orthoses.

Bracing is a common modality in treating spinal fractures. Its objective is to reduce spinal movements and to stabilize the fracture. Until now, factual insight into the movement-reducing properties of Thoraco-Lumbar-Sacral Orthoses (TLSOs) has been missing. Two common TLSOs (e.g., Jewett and Voigt-Bähler) were tested for their movement-reducing properties in two small groups of healthy subject...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 15  شماره Special Issue-12th. Iranian Congress of Medical Physics

صفحات  271- 271

تاریخ انتشار 2018-12-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023