Effect of Aerobic Training on Coagulant Activity in Healthy Young Men

Introduction: Effects of exercise on different body systems, especially cardiovascular and musculoskeletal systems are evidenced. There is a dynamic homeostatic balance between coagulation and fibrinolysis in normal circulation. Effect of exercise and training on this homeostatic balance has been studied extensively but there are a few studies with regards to analysis of the effects of training programs on coagulation factors. Therefore, we studied the effect of 8 weeks aerobic training program on coagulation factors in healthy young men. Methods: Subjects were 16 young sedentary men without any history of cardiac, coagulation or respiratory problems in their first-degree family and their cardiovascular health was confirmed by a cardiac specialist. We randomly selected 10 of them as test group who participated in a submaximal training program on cycle ergometer 3 times a week for 8 weeks. Each training session consisted of 1 minute warm up, 15 minute aerobic exercise, 8 minute active recovery and 45 minute passive recovery. The remaining individuals were controls and restrained from exercise in this period. Before and after training period, response of coagulation system to a submaximal exercise on cycle ergometer was studied by a standardized Ergometery test. Results: Basic value of coagulation variables were the same in both groups before and after training period. After 8 weeks, there was no significant change in anthropometric variables in both groups and so the change in blood variables was independent to physical characteristics of individuals. After 8 weeks of aerobic training, FVIII:c, FIX:c, Fbg and vwF:ac increased in response to exercise that was statistically significant only in Tr group. There was a significant decrease in vwF:ag, aPTT, FVII in this group. We conclude that 8 weeks aerobic training enhances the response of FVIII:c, FIX:c, FVII:c, vwF:ac, Fbg and aPTT to exercise but has no effect on the response of vwF:ag and PT. Conclusion: It seems that the recommended aerobic exercise training protocol will enhance the response of coagulation factors to one session of Ergometric exercise in healthy young men. Due to the importance of blood homeostasis and the effects of coagulation and fibrinolysis imbalance, any type of physical activity especially any exercise program should be analyzed carefully for its effect on haemostatic balance.