Dosimetry Impact of Boron and Its Carriers Structure at Boron Neutron Capture Therapy of a Brain Tumor; A Sim- ulation Study
نویسندگان
چکیده مقاله:
Introduction: Boron neutron capture therapy (BNCT) is a method of cancer treatment and potentially, two borono-L-phenylalanine (BPA) and sodium borocaptate (BSH) are used in BNCT as common boron carriers. Some previous studies have shown that the dose rate is directly related to boron concentration in the tissue. This study aimed to simulate the structure of boron carriers and brain tumor compounds according to the real clinical condition. Moreover, the effect of carrier concentration in tumor volume and boron concentration in carrierschr('39') structure would be numerically assessed. Methods: First, a phantom is developed by FLUKAsimulation code to perform dosimetry aspects of Boron and carriers on a typical brain tumor. Moreover, the components of carriers were then simulated separately and the dosimetry parameters were assessed by changing the amount of boron in the carriers’ structure and by the carrierschr('39') concentration variations inside and around the tumor to mimic the real condition. Results: The results showed that by increasing boron inside the BPA structure from 5.17% to 50%, the dose will be increased up to 78.46%. In the BSH, tumor dose is raised to 9.06% by increasing the amount of boron concentration at carrier structure from 59% to 80%. Moreover, by enhancing the two carrierschr('39') concentration inside the tumor volume up to 30%, the dose value is increased up to 9.59% and 3.20% for BPA and BSH carriers, respectively. Conclusions: The level of boron in the carrierchr('39')s structure and also carrierschr('39') concentration is highly remarkable on dose delivery inside tumor volume and surrounding tissues.
منابع مشابه
A Monte Carlo study of SPECT in boron neutron capture therapy for a heterogeneous human phantom
Background: Boron neutron capture therapy (BNCT) is a binary radiotherapy combining biochemical targeting with neutron irradiation. However, monitoring the boron distribution is a fundamental problem in BNCT. Prompt gamma rays emitted by boron capture reaction can be used to address the issue. Materials and Methods: The general-purpose Monte Carlo toolkits Geant4 and MCNP were used for the simu...
متن کاملBoron Neutron Capture Therapy
A project aimed at the development of an accelerator facility devoted to Boron Neutron Capture Therapy (BNCT) is ongoing at the National Atomic Energy Commission of Argentina [1]. In a first stage of development, the accelerator will be capable of delivering proton or deuteron beams of 30 mA at about 1.4 MeV which is suitable for neutron production through the 9Be(d,n) reaction. In this context...
متن کاملAn investigation into the potential applicability of gel dosimeters for dosimetry in boron neutron capture therapy
Background: The aim of this work was to establish how well gel dosimeters performed, as substitutes for brain tissue compared with standard phantom materials such as water, polymethyl-methacrylate (or PMMA), A150 plastic and TE- liquid phantom material for dosimetry of neutron beams in boron neutron capture therapy. Materials and Methods: Thermal neutron fluence, photon dose and epithermal neu...
متن کاملThe Dosimetry Calculation for Boron Neutron Capture Therapy
BNCT incorporates the targeting principles of chemotherapy and the anatomical localization principles of conventional radiotherapy but with three distinct advantages: Current boron compounds at the required concentrations are non-toxic. The time interval between drug administration and neutron irradiation can be chosen to maximize the concentration differential between tumour and normal tis...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 5 شماره 3
صفحات 1- 7
تاریخ انتشار 2021-07
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023