Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody
نویسندگان
چکیده مقاله:
این مقاله چکیده ندارد
منابع مشابه
Ofatumumab: a novel monoclonal anti-CD20 antibody
Ofatumumab, a novel humanized monoclonal anti-CD20 antibody, was recently approved by the FDA for the treatment of fludarabine and alemtuzumab refractory chronic lymphocytic leukemia (CLL). Ofatumumab effectively induces complement-dependent cytotoxicity (CDC) in vitro, and recent studies demonstrated that ofatumumab also effectively mediates antibody-dependent cellular cytotoxicity (ADCC). Pha...
متن کاملAutophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab
Autophagy has been emerging as a novel cytoprotective mechanism to increase tumor cell survival under conditions of metabolic stress and hypoxia as well as to escape chemotherapy-induced cell death. To elucidate whether autophagy might also protect cancer cells from the growth inhibitory effects of targeted therapies, we evaluated the autophagic status of preclinical breast cancer models exhibi...
متن کاملChimeric Antitenascin Monoclonal Antibody 81C6
1Department of Radiology, Duke University Medical Center, Durham, North Carolina; 2The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina; 3Department of Medicine, Duke University Medical Center, Durham, North Carolina; 4Department of Surgery, Duke University Medical Center, Durham, North Carolina; and 5Department of Pathology, Duke University Medica...
متن کاملDevelopment of a novel anti ESAT-6 monoclonal antibody for screening of Mycobacterium tuberculosis.
Tuberculosis (TB) is a major global public health problem with an estimated one-third of the world's population infected with Mycobacterium tuberculosis, thus necessitating fast and accurate diagnosis of TB. However, the diagnosis of latent infection remains difficult due to the lack of a simple, reliable test for M. tuberculosis infection. The objective of the current study was to generate and...
متن کاملGA101 (a Novel Anti-CD20 Monoclonal Antibody)-Induced Lichenoid Eruption
INTRODUCTION Obinutuzumab (GA101) is a novel anti-CD20 monoclonal antibody that has been shown to be effective for the treatment of non-Hodgkin's lymphoma, and is currently being evaluated in phase 3 clinical trials. The side-effect profile of the drug is not yet well established. CASE REPORT The authors report a case of a 62-year-old patient who developed widespread lichenoid eruption as a r...
متن کامل99mTc Direct radiolabeling of PR81, a new anti-MUC1 monoclonal antibody for radioimmunoscintigraphy
Introduction: Monoclonal antibodies labeled mainly with 99mTc are being widely used as imaging agents in nuclear medicine. Recently PR81 was introduced as a new murine anti-MUC1 MAb against human breast carcinoma. This antibody reacts with the tandem repeat of 20-mer peptide of protein backbone, and is of IgG1 class, with an affinity of 2.19×10-8 M-1. Due to high sp...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 16 شماره 1
صفحات 26- 42
تاریخ انتشار 2019-03-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023