Curcumin and Quercetin Ameliorated Cypermethrin and Deltamethrin-Induced Reproductive System Impairment in Male Wistar Rats by Upregulating The Activity of Pituitary-Gonadal Hormones and Steroidogenic Enzymes
نویسندگان
چکیده مقاله:
Objective Indiscriminate use of synthetic pyrethroid insecticides, Cypermethrin (Cyp) and Deltamethrin (Del) have been reported to cause system toxicity in mammals including humans. The dietary antioxidants protects tissues and organs against insecticides/xenobiotic induced damage. In present study, we evaluated the effect of exposure of Cyp and Del and possible protective roles of curcumin and quercetin on reproductive system of male Wistar rats. MaterialsAndMethods In this controlled experimental study, 42 male Wistar rats were randomly divided into 7 groups of 6 animals each. Group A served as control, group B was exposed to Cyp (2mg /kgbw), group C Del (2mg/ kgbw), group D Cyp+Del (2mg/ kgbw each), group E Cyp+Del, treated with curcumin (100mg/ kgbw), group F Cyp+Del, treated with quercetin (100mg/kgbw) and group G Cyp+Del, treated with quercetin+curcumin (100mg/ kgbw each) for 45 days. Results Exposure to Cyp and Del caused decrease in reproductive organ weight, sperm count, sperm motility, level of sex hormones viz. Testosterone (T), Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH), steroidogenic enzymes viz. 3-β Hydroxysteroid Dehydrogenase (3-βHSD) and 17-β Hydroxysteroid Dehydrogenase (17-β HSD) non-enzymatic antioxidant Glutathione (GSH) and enzymatic antioxidants viz. Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx), Glutathione-S-Transferase (GST) and Glutathione Reductase (GR) activity and increase in sperm abnormalities and Lipid Peroxidation (LPO). The exposure also adversely affected the histo-achitecture of testes. Single and combined treatment with curcumin and quercetin significantly ameliorated Cyp and Del induced damage in reproductive system and preserved the normal histo-architecture of the testes. Conclusion Curcumin and quercetin protected against Cyp and Del induced reproductive system toxicity and oxidative damage in rats. The increase in activities of steroidogenic enzymes (3-βHSD and 17-β HSD) and concomitant increase in testosterone was mainly responsible for ameliorating effect of curcumin and quercetin. Curcumin showed slightly better activity as compared to quercetin. The combination of both antioxidants offered more protection compared to treatment by either.
منابع مشابه
Curcumin and Quercetin Ameliorated Cypermethrin and Deltamethrin-Induced Reproductive System Impairment in Male Wistar Rats by Upregulating The Activity of Pituitary-Gonadal Hormones and Steroidogenic Enzymes
Background Dietary antioxidants protect tissues and organs against insecticides/xenobiotic-induced damage. In the present study, we evaluated the results of exposure to synthetic pyrethroid insecticides, cypermethrin (Cyp) and deltamethrin (Del) and possible protective effects of curcumin and quercetin on reproductive system in male Wistar rats. MATERIALS AND METHODS In this controlled experi...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولSulpiride-Induced Hyperprolactinemia in Mature Female Rats: Evidence for Alterations in The Reproductive System, Pituitary and Ovarian Hormones
متن کامل
Effects of Cypermethrin on Sexual Behaviour and Plasma Concentrations of Pituitary-Gonadal Hormones
Background Pyrethroids are commonly used as insecticides for both household and agricultural applications, and have recently been linked to endocrine disruption. Cypermethrin is a type П pyrethroid which is used widely throughout the world. The present study was aimed to investigate the effects of cypermethrin on the sexual behaviour and plasma level of pituitary-gonadal hormones of adult male ...
متن کاملInteraction between the antioxidant activity of curcumin and cholinergic system on memory retention in adult male Wistar rats
Objective(s): The cholinergic system plays an important role in learning and memory. This study investigated the effects of curcumin (turmeric extract) and the cholinergic system and their interaction on memory retention of passive avoidance learning in adult male Wistar rats. Materials and Methods: At first, an injection cannula was implanted in right ventricles of the animals. One week afte...
متن کاملThe effects of Quercetin on memory and oxidative stress impairment due to Malathion poisoning in male Wistar rats
Malathion is one of the commonest type of organophosphate insecticide whose toxicity in human body is mainly considered to result from the induction of oxidative stress. The aim of this study was to investigate the antioxidant effect of Quercetin, a flavonoid compound, on the spatial memory and oxidative stress parameters during Malathion poisoning in male Wistar rats. This study was performed ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 12 شماره 1
صفحات 72- 80
تاریخ انتشار 2018-06-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023