Comparison of PSA profile with positive prostate cancer pathology and Gleason scores in 2015-2017 in Hamadan

Background and Objective: Prostate cancer is one of the most common cancers of the urinary system. The most used method for diagnosis is transrectal ultrasonography-guided biopsy. The purpose of this study is a statistical analysis with the aim of reducing unnecessary biopsies based on individual, geographical and genetic patterns in our region. Methods: The medical records of all patients who underwent prostate biopsy in Shahid Beheshti Hospital, Hamadan, Iran, during 2015-2017 were reviewed and the data obtained from their study were evaluated by the researcher. Results: Of patients 72.4% had total prostate-specific antigen (PSA) equal to or greater than 10 ng/mL. the majority of patients had benign prostatic hyperplasia (67.4%). Most of the patients had PSAD and F / T above 15% (61.3%) and 18% (52.3%), respectively. By the increasing of total PSA, the percentage of people with prostate cancer increased, and there was a significant relationship between total PSA and the presence of prostate cancer. But for PSAD and F/T there was no significant relationship with prostate cancer. The minimum total PSA in the prostate cancer group was 5.40. Conclusion: In order to reduce unnecessary biopsies and related complications as well as stress imposed on the patient and his family, in this geographical area, we may be able to avoid biopsy in PSA level below 5/4, especially in older ages with normal physical examination and no risk factor. Certainly, to achieve a practical regional guideline, we will need more comprehensive and prospective studies in future.