Comparison of Immune Responses following Intradermal and Intramuscular Rabies Vaccination Methods
نویسندگان
چکیده مقاله:
Rabies is a zoonotic viral disease. The causative agent is a negative-sense RNA genome virus of the genus Lyssavirus (Family: Rhabdoviridae). The disease, commonly transmitted by rabid dogs, is the cause of mortality of over 59000 humans worldwide annually. This disease can be prevented before the development of symptoms through proper vaccination even after exposure. Hence, improvement of the vaccination schedule in the countries where rabies is endemic is essential. In addition to the type of vaccine, injection routes also contribute to enhanced immune responses and increased potency of the vaccines. The vaccines approved by the World Health Organization (WHO) include cell culture and embryonated egg-based rabies vaccines (CCEEVs). In order to develop a vaccine against rabies, it is necessary to use an appropriate delivery system to promote a proper antigen-specific immune response. Different routes of injection such as intradermal (ID), intramuscular (IM) or subcutaneous (SC) are practiced, with controversies over their suitability. In this article, we discuss the immunological aspects of rabies vaccination by comparing ID and IM delivery systems.
منابع مشابه
Cellular immune response following pre-exposure and postexposure rabies vaccination by intradermal and intramuscular routes
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15 صفحه اولIntradermal route for rabies vaccination should be generalized in travelers.
TO THE EDITOR—We agree with Wieten and colleagues [1] that an abbreviated intradermal (ID) schedule would greatly reduce preexposure rabies vaccination cost, including for travelers [2, 3]. However, because lyophilized vaccines do not contain a preservative, once reconstituted, an ampoule must be kept in a refrigerator at <8°C and used within 8 hours. Therefore, for this approach to be costeffe...
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عنوان ژورنال
دوره 6 شماره 4
صفحات 77- 86
تاریخ انتشار 2018-10
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