Comparison of demographic, clinical and endoscopic characteristics of peptic ulcer due to Helicobacter Pylori and NSAIDs

Background: Helicobacter Pylori (H.P) and Non Steroidal Anti inflammatory Drugs (NSAID) are the most common cause of peptic ulcer Disease (PUD). This study was designed to identify endoscopic, clinical and demographic features of patients with H.P positive in comparison with NSAID related PUD.Methods: From December 2004 to March 2008, 5885 patients underwent upper GI Tract endoscopy in a large referral Teaching Hospital of Babol Medical University. All patients with endoscopic diagnosis of PUD were enrolled in the study. H.P positive patients were assigned as group A and NSAID user as group B. Then their clinical, demographic, endoscopic characteristics were compared.Results: A total of 749 (12.3%) patients diagnosed as Duodenal Ulcer (DU), among them 600 subjects were eligible for analysis. Three hundred thirty one (55.2%) were H.P positive, 80 (13.3%) were NSAID user and 189 (31.5%) had non H.P non NSAID related ulcer. Two hundred ninety seven patients diagnosed having Gastric Ulcer (G.U), 143 (48.2%) were H.P positive, 46 (15.5%) were NSAID user and 108 (36.3%) had non H.Pylori, non NSAID related ulcer. Mean age of patients with G.U was 54.2±17 and D.U was 46.9±17.5 years (p<0.04). Anterior wall of bulb and antrum were the most common site of patients with D.U and G.U respectively. Conclusion: This study shows non H.Pylori non NSAID related ulcers comprise a significant portion of peptic ulcer disease in north of Iran.