Comparing the level of plasma Malone dialdehide (MDA) in LD contraceptive pill and condom users

Background: Among the non-surgical methods of preventing conception, taking oral contraceptive pills is the most common way. Some of the studies have shown that contraceptive pills due to containing estrogen and progesterone cause lipid peroxidation and as a consequence increase the level of oxidative stress. Aim: To compare the level of plasma Malone dialdehide in LD contraceptive pill and condom users. Method: In this study, 80 women who were taking LD contraceptive pills to prevent pregnancy and 38 women who used condom were selected from clients who referred to Shiraz health centers (Mehr& Samenolaeme) Plasma Malon dialdehyde was measured by thiobarbituric acid method. Data were analyzed with SPSS Software version 17, using Mann-Whitney and t-test. Results: The mean level of plasma Malon dialdehyde in contraceptive pill users was (4/19±0/836 Ng/ml) and in condom users was (3/32±0/758 Ng/ml). In order to evaluate the differences between two groups t-test showed statistically significant difference in the level of plasma Malon dialdehyde in contraceptive pill and condom users. Conclusion: This study showed that oral contraceptive pills increase plasma Malone dialdehide.