Comparative Computational Studies of 1,4-Diformyl-piperazine and 1,4-Dithionyl-Piperazine

Piperazine-1,4-diium diacetate

In the title salt, C(4)H(12)N(2) (2+)·2C(2)H(3)O(2) (-), the piperazine-1,4-diium cation has 2/m symmetry with the NH(2) unit located on a mirror plane and the acetate anion has m symmetry with all non-H atoms and one H atom located on a mirror plane. The piperazine ring adopts a chair conformation. In the crystal, the cations are linked with the anions via N-H⋯O hydrogen bonding into chains pa...

Tetra­phenyl piperazine-1,4-diyldiphos­pho­nate

The mol-ecule of the title compound, C(28)H(28)N(2)O(6)P(2), is organized around an inversion center located at the centre of the piperazine ring. Both piperazine N atoms are substituted by P(O)(OC(6)H(5))(2) phospho-ester groups. The P atoms display a slightly distorted tetra-hedral environment; the N atoms show some deviation from planarity. The O atoms of the P=O groups are involved in inter...

Piperazine-2,3,5,6-tetra­one. Corrigendum

Piperazine-2,3,5,6-tetra­one

The mol-ecule of the title compound, C(4)H(2)N(2)O(4), is located around an inversion center and the four O atoms are in the 2,3,5,6-positions of the piperazine ring. In the crystal, bifurcated N-H⋯O hydrogen bonds link the mol-ecules into a corrugated layer parallel to (101).

Some pharmacological properties of piperazine.

1. The action of piperazine on mammalian smooth, cardiac and skeletal muscles has been studied.2. Piperazine increased tone and produced a dose dependent contraction of isolated smooth muscle, which was antagonized by atropine.3. With cardiac muscle, piperazine depressed both the rate and force of contraction and was antagonized by atropine. At higher concentrations, a non-specific depression o...

1,4-Bis(2-diazo­acet­yl)piperazine

The asymmetric unit of the title compound, C8H10N6O2, contains one-half mol-ecule, which is completed by a crystallographic center of symmetry. The piperazine ring adopts a chair conformation. In the crystal, weak C-H⋯O inter-actions link the mol-ecules into layers parallel to the bc plane. The crystal packing also exhibits short N⋯N contacts of 3.0467 (16) Å between the terminal diazo N atoms ...