CHROMOSOMAL PROTEINS IN PULMONARY ALVEOLAR MACROPHAGES

chromosomal proteins in pulmonary alveolar macrophages

in this study the nature of chromosomal proteins, his tones and nonhistone in resident alveolar macrophages was investigated in comparison to peritoneal neutrophils and calf thymus proteins. cells were obtained by lavaging the lung and after purity determination they were subjected to fractional extraction procedures. proteins were then analysed on sds polyacrylamide gels and densitometric scan...

Pulmonary alveolar proteinosis: abnormal in vitro function of alveolar macrophages.

Pulmonary alveolar proteinosis is characterized by the accumulation of granular proteinaceous material within the alveoli of the lung. It is well established that patients with pulmonary alveolar proteinosis have a high incidence of complicating pulmonary infections, which suggests that the function of the alveolar macrophages is abnormal. To investigate the function of these cells, they were o...

Pulmonary alveolar proteinosis. Further evaluation of abnormal alveolar macrophages.

To investigate the function of alveolar macrophages (AM) and the mechanisms of impairment in pulmonary alveolar proteinosis, we established in culture AM from three patients and from eight normal nonsmokers and assessed phagocytosis and phagolysosome fusion by the acridine orange assay with live yeast as the phagocytic challenge. Alveolar macrophages from the patients with pulmonary alveolar pr...

Pulmonary alveolar macrophages in molecular epidemiology and chemoprevention of cancer.

In addition to possessing an extraordinary sweeping activity, pulmonary alveolar macrophages (PAM) are equipped with the biochemical mechanisms involved in the metabolism of carcinogens, which were found to be inducible in humans by cigarette smoke. Moreover, several defense processes were stimulated in rat PAM after in vivo administration of the anticarcinogen N-acetylcysteine (NAC). Benzo[a]p...

Protective Effects in Pulmonary Tuberculosis Depletion of Alveolar Macrophages Exerts

Alveolar macrophages as biomarkers of pulmonary irritation in kitchen workers.

OBJECTIVES Alveolar macrophages (AM) are used as a biomarker of pulmonary irritation due to occupational exposure in the AM test. The aim of this study was to investigate whether there is a co-variation between the number of AM and exposure to cooking fumes. MATERIALS AND METHODS The study group consisted of 62 volunteers. People who worked in a kitchen preparing hot meals were considered as ...