Brain Single Photon Emission Computed Tomography Scan (SPECT) and Functional MRI in Systemic Lupus Erythematosus Patients with Cognitive Dysfunction: A Systematic Review
نویسندگان
چکیده مقاله:
Objective(s): Systemic lupus erythematosus (SLE) is an autoimmune disease with a wide range of clinical manifestations. Cognitive dysfunction is one of the manifestations that could present prior to the emergence of any other neuropsychiatric involvements in SLE. Cognitive dysfunction is a subtle condition occurring with ahigh frequency. However, there is no data on the correlation of cognitive dysfunction with central nervous system (CNS) imaging findings, in particular single-photon emission computed tomography scan (SPECT) and functional MRI. We decided to perform a systematic review of brain SPECT and fMRI in SLE patients with cognitive dysfunction.Methods: PubMed, Scopus, and Google Scholar databases were searched until April 2017 with the following keywords: “SLE OR systemic lupus erythematous OR lupus” AND “functional MRI OR functional magnetic resonance imaging OR fMRI OR SPECT or SCAN”. A total of 1,767articles were found. Two rheumatologistsreviewed the articles and finally 14 articles were selected for the final systematic review.Results: The fMRI and SPECT imaging techniques could provide valuable information regarding the SLE patients with cognitive dysfunction at the early stages of the disease.Conclusion: Brain SPECT scan and fMRI are used as functional imaging tools in SLE. Both of these diagnostic modalities are sensitive in reflecting the subtle brain damages in SLE patients with cognitive dysfunction. Brain fMRI and SPECT scan could be significantly beneficial in the diagnosis and initial management of cognitive dysfunction in SLE. Nevertheless, prospective studies could be useful in confirming the application of these diagnostic modalities in the clinical setting.
منابع مشابه
Single-photon emission computed tomography (SPECT) and intractable epilepsy.
TAPANI TIKKAKOSKI Editor In patients with intractable epilepsy refractory to medication, surgical treatment may be needed. Magnetic resonance imaging (MRI) is an essential neuroimaging tool in assisting the identifi cation of epileptogenic lesions. MRI at 3T has been found to perform better than 1.5T in terms of image quality, detection of structural lesions, and characterization of lesions. Th...
متن کاملCognitive dysfunction in patients with Systemic Lupus Erythematosus
OBJECTIVE To determine the extent to which cognitive dysfunction (CD) observed in patients with systemic lupus erythematosus (SLE) exceeds that seen in a matched control group of patients with rheumatoid arthritis (RA), and to estimate the prevalence of CD in SLE in a community-based sample. METHODS A random subsample of 31 patients with SLE was compared to patients with RA matched by age, se...
متن کاملThe Clinical Applications of Single-photon Emission Computed Tomography and Computed Tomography (spect/ct) in Oncology
The accurate evaluation of a tumor’s stage is one of the most important steps for successful treatment. Radionuclide imaging, now widely used, is useful because it may reflect not only morphological characteristics but also metabolic activities. Conventional imaging techniques can provide anatomical information, necessary for the accurate detection and localization of structural and morphologic...
متن کاملImage Optimization in Single Photon Emission Computed Tomography by Hardware Modifications with Monte Carlo Simulation
Introduction: In Single Photon Emission Computed Tomography (SPECT), the projection data used for image reconstruction are distorted by several factors, including attenuation and scattering of gamma rays, collimator structure, data acquisition method, organ motion, and washout of radiopharmaceuticals. All these make reconstruction of a quantitative SPECT image very difficult. Simulation of a SP...
متن کاملSingle photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice.
Noninvasive analysis of renal function in conscious mice is necessary to optimize the use of mouse models. In this study, we evaluated whether single photon emission-computed tomography (SPECT) using specific radionuclear tracers can be used to analyze changes in renal proximal tubule functions. The tracers included (99m)TC- dimercaptosuccinic acid ((99m)Tc-DMSA), which is used for cortex imagi...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 6 شماره 2
صفحات 97- 107
تاریخ انتشار 2018-06-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023