Brain metabolites Associated with Common Clinical Symptoms of multiple sclerosis patients Using MagneticResonance Imaging

Introduction: Multiple Sclerosis (MS) is an auto-immune disease that involves central nervous system (CNS). Magnetic Resonance Spectroscopy (MRS) is an analytical non- invasive method for obtaining the pathologic data of disease and it brings biochemical information about studied tissue which can be helped in studying the reasons and development process of disease and it increases the sensitivity of diagnosing for physicians. This method especially in studying of brain’s disease had many advances. In present investigation it was trying to demonstrate the abilities of this method in studying and primary, differential diagnosing in the various different sub-groups of multiple sclerosis disease. Materials and Methods: in this research 31 patients who affected to multiple sclerosis (12 women, 4 men) RRMS, (7 women, 8 men) PPMS, 15 health people as control group participated in the study. Proper imaging protocols and MRS protocol was done for each patient and two parts of patient’s brain, respectively. One step with VOI selection in plaque region and other step in a normal region of withe tissue of brain (NAWM). By using statically tests the comparison between metabolites rate was evaluated in three sub-groups of disease and also it was done a comparison between the rates of metabolites in two regions of NAWM and plaque. Thus, 15 health people as control group was tested with those protocol by MRS and brain’s metabolites compared with patients metabolites. Results: the rate of Cr metabolite in NAWM region has meaningful differences of P=0.03 between two sub-groups of PPMS, RRMS. In PPMS subgroup the rate of NAA showed meaningful difference of P=0.026 between NAWM and the plaques. The ratio of Cr/NAA in tissue of the substance white brain is meaningfully more than this ratio in plaque related to PPMS (P=0.007) sub-group. Conclusion: the results of this study demonstrated that with surveying the rate of Cr or Cr/NAA in MS plaque can be diagnosed patients in two RRMS and PPMS sub-groups from each other.