Bone marrow stromal cells can promote the neurogenesis in subventricular zone in the rat with focal cerebral ischemia

bone marrow stromal cells can promote the neurogenesis in subventricular zone in the rat with focal cerebral ischemia

introdution: stroke is one of the most common diseases caused by occlusion or rupture of blood vessels in brain. it brings heavily loads for families and societies. although some new strategies including treatment of tissue plasminogen activator have been applied in the clinic, these methods do not have perfect effect. accordingly, more effective therapeutic strategies need to be developed. thi...

Bone Marrow Stromal Cells Can Promote The Neurogenesis in Subventricular Zone in The Rat With Focal Cerebral Ischemia

Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat.

Because neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, we investigated its possible involvement in the brain's response to focal cerebral ischemia. Ischemia was induced by occlusion of the middle cerebral artery in the rat for 90 min, and proliferating cells were labeled with 5-bromo-2'-deoxyuridine-5'-monophosphate (BrdUrd) ove...

The Effect of TGF-alpha on Neurogenesis in Subventricular Zone of Rat Brain after Ischemia-Reperfusion

Introduction: Stroke is the third important reason of death in adults and an important cause of adult disability. Previous studies suggest that TGF-alpha can induce neurogenesis after stroke. Here in, we studied neurogenesis effects of the TGF-alpha on subventricular zone following ischemia-reperfusion. Male wistar rats (250-300 g) were divided into ischemia and treatment groups. After inductio...

Toxicity Study Of gelatin-chitosan Films with Bone Marrow Stromal Cells Cultured in Rat

Background :Gelatin and chitosan are known as biodegradable and biocompatible biopolymers.These biopolymers have recently receivedincreasingly more attention for tissueengineering.The aim of this study was to evaluate the toxicity effects of gelatin-chitosan film on bone marrow stromal cell(BMSCs) culture in rat.                                                  Materials & Methods: First, gel...

Sodium orthovanadate enhances proliferation of progenitor cells in the adult rat subventricular zone after focal cerebral ischemia.

Neuronal progenitor cells able to produce new neuron and glia persist in the adult central nervous system (CNS). Their proliferation is up-regulated by growth factors or cytokines under some pathological conditions, including ischemia. Because sodium orthovanadate (SOV), a protein tyrosine phosphatase inhibitor, can up-regulate tyrosine kinase-linked growth factor receptor signaling via the inh...