Blood Cell Growth Factors
نویسنده
چکیده مقاله:
SUMMARY Growth factors or colony stimulating factors (CSFs)recently became the subject of headlines around the world. Many published articles in the last few years indicate that the CSFs can correct anemia and pancytopenia of the great majority of patients. Recombinant CSFs are available to the many scientific and therapeutic centers in the U.S.A, Europe and Japan these days. Erythrop oietin (EPO)incre ases hemoglobin and hematocrit levels in patients with endstage renal disease, advanced cancer disease, those anemias due to chemotherapy, AIDS and chronic infections. Four highly active glycoprotein regulators, the colony stimulating factors, GM-CSF, G-CSF, M-CSF and IL3 are responsible in the formating, maturation and functional activity of Granulocytes, Monocytes and Macrophages. Each regulator is polyfunctional. While each factor has some distinctive action, to a large part CSFs overlap in their actions, and individual cells can simultaneously respond to more than one factor. The CSFs have now been isolated and purified. Their biologically active recombinant form produced. More recently, CSF membrane receptors have been recognized on individual cells. When injected in vivo. recomhinant CSFs are able to increase production of granulocytes and macrophages in a distinctive pattern of response. The functional activity of the mature granulocytes and monocytes not only is enhanced by CSFs, but also the injection of CSF has been shown to increase resistance to infections and reduce mortality from whole body irradiation or chemotherapy. Clinical trials to date have been most extensive of G.CSF and GM.CSF, both of which are able to elevate blood and bone marrow levels of granulocytes and monocytes of disease. States including AIDS. hypoplastic stage following cancer chemotherapy or marrow transplantation and the myelodys - plastic syndrome. The clearest evidence so far of the ability of CSFs to enhance resistance to infections has come from the studies on patient with cyclic or congenital neutropenia. the relative low toxicity of the CSFs indicate a future use of these agents in clinical medicine. It may effect a revolution in medicine as the introduction of antibiotics half a century ago.
منابع مشابه
The Beijing Blood Cell Growth Factors Symposium--blood cell growth factors: their present and future use in hematology and oncology.
In this age of modern era, the use of internet must be maximized. Yeah, internet will help us very much not only for important thing but also for daily activities. Many people now, from any level can use internet. The sources of internet connection can also be enjoyed in many places. As one of the benefits is to get the on-line blood cell growth factors their present and future use in hematolog...
متن کاملThe association between growth factors and blood factors with early childhood caries
BACKGROUND AND AIM: Early childhood caries (ECC) is a specific form of rampant dental caries affecting infants and young children. ECC is still a problem that threatens the health of the community and its management is important. It is believed that the majorities of children with ECC also suffer from malnutrition, anemia, low weight and altered physical growth patterns. This study was undertak...
متن کاملNutritional factors in blood-cell formation.
In recent years our knowledge of the formation, nutrition and metabolism of the cells of the blood has been greatly advanced by studies with the electron microscope, from tagging various nutrients and precursors with radioactive tracers, by advances in staining methods, by the use of specific enzymes to attack substances in particular regions of cells and of absorption-spectra techniques and va...
متن کاملCytokine receptors, growth factors and cell cycle in human bone marrow and peripheral blood hematopoietic progenitors.
BACKGROUND AND OBJECTIVE An increasing number of growth factors have been shown to be responsible for the proliferation, survival and enhanced function of many cell types within the hemopoietic system. The action of these hemopoietic growth factors in stimulating cell growth and survival applies both to cells within the progenitor compartment and mature cells. Whether a specific cytokine influe...
متن کاملPeripheral blood stem cell mobilization in multiple myeloma: Growth factors or chemotherapy?
High-dose therapy followed by autologous hematopoietic stem cell (HSC) transplant is considered standard of care for eligible patients with multiple myeloma. The optimal collection strategy should be effective in procuring sufficient HSC while maintaining a low toxicity profile. Currently available mobilization strategies include growth factors alone, growth factors in combination with chemothe...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 16 شماره 1
صفحات 19- 26
تاریخ انتشار 1992-03
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023