Attenuation of N-nitrosodimethylamine induced hepatotoxicity by Operculina turpethum in Swiss Albino mice
نویسندگان
چکیده مقاله:
Objective(s): To appraise the antihepatotoxic efficacy of ethanolic extract of Operculum turpethum root on the liver of Swiss albino mice. Materials and Methods: Hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of N-nitrosodimethylamine (NDMA) at the concentration of 10 mg/kg body weight. The liver toxicity and therapeutic effect of the plant ethanolic extract was assessed by the analysis of liver marker enzymes and antioxidant enzymes and liver histopathological studies. Results: Hepatotoxicity was manifested by significantly decreased (P
منابع مشابه
attenuation of n-nitrosodimethylamine induced hepatotoxicity by operculina turpethum in swiss albino mice
objective(s): to appraise the antihepatotoxic efficacy of ethanolic extract of operculum turpethum root on the liver of swiss albino mice. materials and methods: hepatic fibrosis was induced in adult male albino mice through intraperitoneal administrations of n-nitrosodimethylamine (ndma) at the concentration of 10 mg/kg body weight. the liver toxicity and therapeutic effect of the plant et...
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The root extract of Operculina turpethum (OTE) has been used as an anti-inflammatory, purgative, and hepato-protective agent. N-Nitrosodimethylamine (NDMA) is a potent hepatotoxin that induces fibrosis of the liver. In the present study, we examined the therapeutic effects of OTE root extract against NDMA-induced hepatotoxicity and clastogenicity in rats. Hepatic fibrosis was induced in adult m...
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N-Nitrosodimethylamine is one of the main N-nitroso compound,commonly found in drinking water and is a potent hepatotoxin, carcinogen and mutagen. The curative effect of ethanolic root extract of Operculina turpethum was studied for its possible hepatoprotective potential against NNitrosodimethylamine in Swiss albino mice. Hepatic malondialdehyde (MDA), Superoxide dismutase(SOD),catalase(CAT),g...
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عنوان ژورنال
دوره 17 شماره 1
صفحات 73- 80
تاریخ انتشار 2014-01-01
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