Association of vitamin D deficiency and premature coronary artery disease
نویسندگان
چکیده مقاله:
Background: Evidence suggests hypovitaminosis D is associated with increased risk of coronary artery disease (CAD) and its extent and related risk factors. However, some investigations have produced contrary results. Therefore, we aimed to evaluate the association between serum vitamin D levels and the severity of premature coronary artery involvement. Methods: This randomized prospective, case-control study was conducted in Babol from April 2013 to June 2017. We collected the demographic data and measured serum 25-OH-D levels of 294 patients (age≤50 years) diagnosed with CAD with coronary angiography as case group as well as 438 age and sex-matched controls. CAD severity was assessed using the Gensini score. Statistical analyses were used to assess the associations and p<0.05 was considered as significant. Results: The mean serum level of 25-OH-D was 13.12±11.13 and 18.28±8.34 in case and control groups, respectively (P=0.036). In the case group, mean serum vitamin D levels were significantly lower among hypertensives (P=0.018), those with a family history of CVD (P=0.016) and those who used aspirin (P=0.036). The mean Gensini score of patients in the case group was 45.02±23.62 and was higher among men (P=0.022). There was a weak significant correlation between the serum vitamin D levels and the Gensini score (P=0.001 & R=-0.543). The mean Gensini score was not significantly different between patients with deficient (47.02±22.78), insufficient (26.0±21.72) and sufficient (39.0±43.84) vitamin D levels (P>0.05). Conclusion: The results showed that the lower levels of vitamin D is associated with increased risk and extent of coronary artery involvement as well as some of the risk factors of CAD, including male gender, hypertension and positive family history for CVD.
منابع مشابه
Association of Vitamin D Level and Subclinical Coronary Artery Disease
There is a growing interest in the various health effects of vitamin D. Vitamin D levels are inadequate in about 50% of the world population [1]. Although vitamin D has traditionally been related to bone health, it is also linked to other chronic conditions, such as cardiovascular disease (CVD). Individuals my receive vitamin D from sun exposure, dietary intake, or supplements. Vitamin D2 is sy...
متن کاملVitamin D Deficiency Accelerates Coronary Artery Disease Progression in Swine.
OBJECTIVE The role of vitamin D deficiency in coronary artery disease (CAD) progression is uncertain. Chronic inflammation in epicardial adipose tissue (EAT) has been implicated in the pathogenesis of CAD. However, the molecular mechanism underlying vitamin D deficiency-enhanced inflammation in the EAT of diseased coronary arteries remains unknown. We examined a mechanistic link between 1,25-di...
متن کاملAssociation of vitamin D deficiency and coronary artery disease with cardiovascular risk factors
BACKGROUND Vitamin D deficiency is a prevalent condition in many countries. The aim of this study is to elucidate whether deficient vitamin D status is associated with coronary artery disease considering cardiovascular risk factors. MATERIALS AND METHODS We measured 25 (OH) D serum levels in 57 patients that were diagnosed with coronary artery disease upon coronary angiography and 62 individu...
متن کاملThe relationship between vitamin D deficiency and coronary artery ectasia
INTRODUCTION The pathophysiology of coronary artery ectasia (CAE) has not been clearly identified although multiple abnormalities including arteritis, endothelial dysfunction, and atherothrombosis have been reported. The role of vitamin D deficiency suggests cardiovascular diseases such as coronary artery disease, heart failure, and hypertension. Vitamin D deficiency activates the renin-angiote...
متن کاملAssociation between Helicobacter pylori Infection and Atherosclerotic Coronary Artery Disease
Background and Objectives: Cardiovascular disease is the most common cause of death in developed countries. In addition to traditional risk factors for cardiovascular disease, nowadays, accumulating evidence indicates that a variety of infections contribute to pathogenesis of atherosclerosis, (We investigated whether Helicobacter pylori infection is related to Prevalence of coronar...
متن کاملAssociation of serum gamma-glutamyltransferase and premature coronary artery disease
BACKGROUND Serum gamma-glutamyltransferase (GGT) has been introduced as a predictive factor for cardiovascular disease. In this study, we investigated the association of serum GGT and premature coronary artery disease (CAD) in candidates for coronary angiography. METHODS In this cross-sectional study, we enrolled male subjects aged ≤45 years and female subjects ≤55 years who were candidates f...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 10 شماره 1
صفحات 80- 85
تاریخ انتشار 2019-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023