Association of CYP1A1*2A Polymorphism with Idiopathic Non-Obstructive Azoospermia in A South Indian Cohort

Objective : Infertility is the inability of a couple to conceive after one and half year of unprotected sex.Infertility is an inability of a person to reproduce, in its normal state or condition. Male infertility is considered as a major problem all over the world. The aim of this study was to investigate the association of the CYP1A1 polymorphisms with idiopathic non-obstructive azoospermia in south Indian cohort. MaterialsAndMethods The samples for fertile and infertile samples were collected and DNA extraction was done and the polymorphism of CYP1A1 gene is carried out by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) as a case control study including 120 infertile patients and 80 fertile men. Results The genotype distribution of CYP1A1 gene showed significant difference in patients and controls. Analysis of CYP1A1 gene resulted, CC allelic genotype associated with decreased risk of idiopathic non-obstructive azoospermia comparison with the TT and TC genotype. Conclusion The present study showed differences in genotypic polymorphism between TT, TC, CC genotypes of CYP1A1 in both infertile (patients) and fertile men (controls).