Association between The Number of Retrieved Mature Oocytes and Insulin Resistance or Sensitivity in Infertile Women Polycystic Ovary Syndrome

Objective The objective of this study was to evaluate LH/FSH and demographic variables on maturation stage of oocytes in patients with polycystic ovary syndrome (PCOS) with or without insulin resistance. MaterialsAndMethods Sixty patients with IVF/ICSI indication were subdivided into 3 groups as follow: 20 subjects were assigned to control (fertile women with male infertility history) group, 20 subjects with PCOS were insulin resistant (IR) and 20 subjects with PCOS were insulin sensitive (IS). After puncture, retrieved oocytes were classified into metaphase II (MII) as mature and in metaphase I (MI) or germinal vesicle stage (GV) as immature. Regression analyses were used to explore the association between MII oocyte number and demographic and clinical variables. Results luteinizing hormone (LH)/ follicle-stimulating hormone (FSH) ratio was significantly higher in PCOS-IR women compared to controls but not significantly different from that of PCOS-IS group. PCOS-IR women had lower MII oocyte number compared with that of controls. According to multiple regression analysis, the number of previous ART cycles was negatively associated with number of MII oocytes. Conclusion Insulin resistance can be associated with MII oocyte number reduction in patients with polycystic ovary syndrome.