Association between serum interleukin-1β levels and perinatal asphyxia

Objective: Asphyxia  is  a  major  cause  of  acute  mortality  and  chronic  neurologic  disability  in  neonates. We sought to  define  the  predictive  values  of  serum  concentrations  of  interleukin-1β  in  newborns  with perinatal asphyxia to see if there is a relation between interleukin-1β (IL-1β) levels to the short term neurological deficit.  Methods: This was a prospective (case-control) study conducted between June 2007 and July 2008, at the Neonatal Intensive Care Unit, Ghaem Hospital, Mashhad, Iran. Serum IL-1β   levels were measured at birth, 24 and 48 h post-partum in 38 consecutive uninfected neonates with perinatal asphyxia(blood  pH< 7.2,  low Apgar  score , signs  of  fetal  distress)  and  41  randomly selected healthy newborns (normal infants free of a postnatal clinical event during the first weeks of life). Receiver-operating characteristic (ROC) curves were used for the determination of thresholds for the asphyxiated group versus healthy neonate group. Results: A total of 79 infants were studied. Serum interleukin-1β concentrations in the infants who developed hypoxic-ischemic encephalopathy was 6 folds higher as compared to values in the normal infants (p< 0.006) and 5-folds higher compared to infants with asphyxia who did not subsequently develop hypoxic-ischemic encephalopathy (p< 0.006). There was also a significant relationship between serum IL-1Β and outcome at the time of discharge. Conclusions: Serum levels of IL-1Β are increased substantially in neonates with asphyxia, and this is most pronounced in neonates with poorer prognosis.