Antiparasitic Activity and Essential Oil Chemical Analysis of the Piper Tuberculatum Jacq Fruit

نویسندگان

  • Adamo Brasil Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Cathia Coronel Center for the Development of Scientific Research, Foundation Moisés Bertoni/Laboratories Diaz Gill, Asunción-Paraguay.
  • Cristina Rodrigues Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Henrique Coutinho Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Irwin Menezes Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Josefa Lacerda Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Maria Gomez Center for the Development of Scientific Research, Foundation Moisés Bertoni/Laboratories Diaz Gill, Asunción-Paraguay.
  • Marta Kerntopf Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Maysa de Oliveira Barbosa Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Saulo Tintino Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
چکیده مقاله:

With the increase of neglected diseases such as leishmaniasis and Chagas disease, there wasa need for the search for new therapeutic alternatives that reduce the harm caused by medicineavailable for treatment. Thus, this study was performed to investigate the antiparasitic activityof the essential oil from the fruits of Piper tuberculatum Jacq, against lines of Leishmaniabraziliensis (MHOM/CO/88/UA301), Leishmania infantum (MHOM/ES/92/BCN83) andTrypanosoma cruzi (LC-B5 clone). Before running protocols, an analysis of the chemicalcomposition of essential oil was conducted, which presented monoterpenes and sesquiterpenes.As major constituents, β-pinene and α-pinene were identified. Regarding to antiparasitic activity,the essential oil had an EC50 values of 133.97 μg/mL and 143.59 μg/mL against variationspromastigotes of L. infantum and L. braziliensis, respectively. As for trypanocidal activity, theoil showed EC50 value of 140.31 μg/mL against epimastigote form of T. cruzi. Moreover, itshowed moderate cytotoxicity in fibroblasts with LC50 value of 204.71 μg/mL. The observedeffect may be related to the presence of terpenes contained in the essential oil, since it has itsantiparasitic activity proven in the literature.

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عنوان ژورنال

دوره 17  شماره 1

صفحات  268- 275

تاریخ انتشار 2018-01-01

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