Anti-Trypanosoma cruzi activity of extracts from Argentinean Asteraceae species

نویسندگان

  • Carla Grosso Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Emilio L Malchiodi Cátedra de Inmunología, Instituto de Estudios de la Inmunidad Humoral (IDEHU) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. |Instituto de Microbiología y Parasitología Médica (IMPaM) (UBA-CONICET), Facultad de Medicina, Buenos Aires, Argentina
  • Flavia Redko Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. |Instituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Buenos Aires, Argentina.
  • Jimena Borgo Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.|
  • Maria Clavin Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. |Instituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Buenos Aires, Argentina
  • Mariana G Selener Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Orlando Elso Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.| Instituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Buenos Aires, Argentina
  • Silvia I Cazorla Centro de Referencia para Lactobacilos (CERELA) (CONICET), San Miguel de Tucumán, Argentina.
  • Valeria P Sülsen Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. |Instituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Buenos Aires, Argentina.
چکیده مقاله:

The anti-Trypanosoma cruzi activity of extracts from 13 Argentinean Asteraceae species was determined. Dichloromethane and methanol extracts of Acmella bellidioides, Aspilia silphioides, Viguiera tuberosa, Calyptocarpus biaristatus, Hyalis argentea, Helenium radiatum, Gaillardia megapotamica, Verbesina subcordata, Gymnocoronis spilanthoides, Viguiera anchusaefolia, Thelesperma megapotamicum, Zexmenia buphtalmiflora and Vernonia plantaginoides were evaluated in vitro against Trypanosoma cruzi epimastigotes. A. silphioides, V. tuberosa, V. subcordata, G. spilanthoides, G. megapotamica, T. megapotamicum and Z. buphtalmiflora dichloromethane extracts showed trypanocidal activity with inhibitions higher than 60% at a concentration of 10 µg/mL. The methanol extracts of H. radiatum and G. megapotamica were the most active with inhibitions of 70.1 and 77.7%, respectively at 10 µg/mL. The chromatographic profiles of the most active extracts showed bands and major peaks that could be attributed to flavonoids and terpenoid compounds.

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عنوان ژورنال

دوره 18  شماره 4

صفحات  1854- 1861

تاریخ انتشار 2019-12-01

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